Identification of potential anti-inflammatory and melanoma cytotoxic compounds from Aegiceras corniculatum
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Medicinal Chemistry Research https://doi.org/10.1007/s00044-020-02613-5
ORIGINAL RESEARCH
Identification of potential anti-inflammatory and melanoma cytotoxic compounds from Aegiceras corniculatum Le Ba Vinh1,2 Nguyen Viet Phong2 Irshad Ali3 Gao Dan1 Young Sang Koh3 Hoang Le Tuan Anh4 Do Thi Van Anh5 Seo Young Yang1 Young Ho Kim 1 ●
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Received: 20 May 2020 / Accepted: 6 August 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Many chemicals found in mangroves reportedly exhibit potent anticancer, antibacterial, anti-inflammatory, antioxidant, and antitumor properties. Several of such compounds include feature unique structures and display interesting pharmacological effects. Few medicinal mangrove plants from Vietnam have been characterized with regard to their chemical constituents. Aegiceras corniculatum (L.) Blanco is a mangrove shrub that exhibits activity against various types of cancer. To identify new secondary metabolites and determine the source(s) of biological activity in Vietnamese medicinal mangrove plants, the chemical constituents of A. corniculatum were isolated, and their structures were appropriately established using common spectroscopic methods (1D and 2D-NMR, IR, HR-ESI-MS), and by producing derivatives by chemical reactions. Complementarily, it is worth noting, that the anti-inflammatory effects of the isolated compounds were investigated by measuring the production of pro-inflammatory cytokines IL-12 p40, IL-6, and TNF-α in lipopolysaccharide-stimulated bone marrow-derived dendritic cells; in this sense, the target compounds 2 and 3 were potent inhibitors of cytokines TNF-α, IL-6, and IL-12 p40, indicating promising anti-inflammatory effects. Furthermore, compounds 1 and 4 strongly promoted apoptosis of B16F10 melanoma cells. It is convenient to highlight, that the obtained results suggest that saponins from A. corniculatum could be potential candidates for treating cancer and inflammatory illnesses. Keywords Aegiceras corniculatum Saponins Anti-inflammatory effect Melanoma cytotoxic inhibitor ●
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These authors contributed equally: Le Ba Vinh, Nguyen Viet Phong Supplementary information The online version of this article (https:// doi.org/10.1007/s00044-020-02613-5) contains supplementary material, which is available to authorized users. * Seo Young Yang [email protected] * Young Ho Kim [email protected] 1
Natural Products Laboratory, College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea
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Department of Marine Medicinal Materials, Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam
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School of Medicine and Jeju Research Center for Natural Medicine, Jeju National University, Jeju 63243, Republic of Korea
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Mientrung Institute for Scientific Research, Vietnam Academy of Science and Technology, Thua Thien Hue 531600, Vietnam
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Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 34134,
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