Mass Spectrometry Imaging Principles and Protocols
Mass spectrometry (MS) offers unmatched capabilities for the detection, characterization, and identification of a broad range of analytes. Mass spectrometry imaging (MSI) integrates MS data with information on the spatial distributions of the analytes, fu
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MO L E C U L A R BI O L O G Y
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For other titles published in this series, go to www.springer.com/series/7651
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Mass Spectrometry Imaging Principles and Protocols
Edited by
Stanislav S. Rubakhin Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, USA
Jonathan V. Sweedler Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA
Editors Stanislav S. Rubakhin Beckman Institute University of Illinois at Urbana-Champaign N. Mathews Avenue 405 61801 Urbana Illinois USA [email protected]
Jonathan V. Sweedler Department of Chemistry University of Illinois at Urbana-Champaign South Mathews Avenue 63-5 600 61801 Urbana Illinois USA [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-60761-745-7 e-ISBN 978-1-60761-746-4 DOI 10.1007/978-1-60761-746-4 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010930696 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface Why should you use the protocols described in this book? In order to characterize many biological systems, having knowledge of their chemical constituents, locations, and dynamics is important. Mass spectrometry (MS) provides unmatched capabilities for detection, characterization, and identification of analytes ranging from individual elements to complex multimolecular structures. A powerful enhancement to MS detection is the addition of spatial information; mass spectrometry imaging (MSI) combines the capabilities of modern MS with imaging. The distribution of hundreds of different analytes in a tissue can be determined in a single experiment. Unlike other imaging approaches, analyte preselection is not needed. Metabolites, peptides, proteins, and polynucleotide
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