Immunomodulatory Agents from Plants
The human immune system, despite having its own sophisticated defence mecha nisms, is inferior to bacteria and viruses with respect to adaptability. Furthermore, our immune system is increasingly exposed to detrimental effects, that is immuno suppressiv
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PLiVA Research Institute Prilaz baruna Filipovica 25 10000 Zagreb Croatia
Immunomodulatory Agents from Plants
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Hildebert Wagner Editor
Springer Basel AG
Editors Prof. Dr. Dr. h.c. H. Wagner Institut fUr pharmazeutische Biologie Ludwig-Maximilians-Universităt Munchen Karlstrasse 29 D-80333 Munchen
A CIP catalogue record for this book is available from the Library of Congress, Washington D.C., USA
Deutsche Bibliothek Cataloging-in-Publication Data Immunomodulatory agents from plants / ed. by H. Wagner - Basel ; Boston; Berlin : Birkhăuser, 1999 (Progress in inflammation research) ISBN 978-3-0348-9763-1 ISBN 978-3-0348-8763-2 (eBook) DOI 10.1007/978-3-0348-8763-2
The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. AII rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of iIIustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained. © 1999 Springer Basel AG Originally published by Birkhiiuser Verlag in 1999 Softcover reprint of the hardcover lst edition 1999
Printed on acid-free paper produced from chlorine-free pulp. TCF = Cover design: Markus Etterich, Basel Cover iIIustration: With the friendly permission of Mayer & Partner GmbH, Frankf. Str. 119, D-63303 Dreieich ISBN 978-3-0348-9763-1 987654321
Contents
List of contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ..
vii
Preface............................................................................
xi
Hildebert Wagner, Stefan Kraus and Kseniia Jurcic Search for potent immunostimulating agents from plants and other natural sources. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1
Rudolf Bauer Chemistry, analysis and immunological investigations of Echinacea phytopharmaceuticals ............................................................ 41 Andreas C. Emmendorffer, Hildebert Wagner and Marie-Luise Lohmann-Matthes Immunologically active polysaccharides from Echinacea purpurea plant and cell cultures. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 89 Dieter Melchart and Klaus Linde Clinical investigations of Echinacea phytopharmaceuticals ....................... 105 Michael 1. Parnham Benefit and risks of the squeezed sap of the purple coneflower (Echinacea purpurea) for long~term ora
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