Impact of Bariatric Surgery on Clinical, Biochemical, and Hormonal Parameters in Women with Polycystic Ovary Syndrome (P
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ORIGINAL CONTRIBUTIONS
Impact of Bariatric Surgery on Clinical, Biochemical, and Hormonal Parameters in Women with Polycystic Ovary Syndrome (PCOS) Devender Singh 1 & Kirit Arumalla 1 & Sandeep Aggarwal 1
&
Vitish Singla 1 & Ashraf Ganie 2 & Neena Malhotra 3
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract There is limited data on the impact of bariatric surgery on polycystic ovarian syndrome (PCOS) especially in the Indian population. Background To study the impact of bariatric surgery in women with PCOS in terms of clinical, hormonal, and radiological aspects of polycystic ovarian syndrome. Methods A prospective observational study of 50 women who underwent bariatric surgery at our tertiary care center. Evaluation of anthropometric data and menstrual cyclicity as well as markers of hyperandrogenism was done preoperatively and at 3- and 6month and 1-year follow-up. Results Eighteen (36%) women were diagnosed to have PCOS. % EWL at 3-months (n = 14), 6-month (n = 14), and 1-year (n = 11) follow-up was 31%, 49%, and 63% respectively among women with PCOS. All females regained their normal menstrual cycle at 3 months of follow-up. Hirsutism resolved completely among 44% (5/11) with a decline in median hirsutism score from 11 to 9 at 1-year follow-up. Mean serum testosterone decreased from 0.83 ± 0.38 ng/ml preoperatively to 0.421 ± 0.25 ng/ml at 1year follow-up (p ˂ 0.01), whereas changes in levels of serum LH and FSH were not significant. Seventy-seven percent of females (14/18) had polycystic ovaries preoperatively on USG; out of which, 55% (i.e., 4/7) showed complete resolution at 1year follow-up. Metabolic syndrome resolved completely at 1-year follow-up in both PCOS and non PCOS group. Conclusions Bariatric surgery results in an effective and sustained weight loss with improvement in clinical, hormonal, and radiological parameters associated with PCOS. Keywords Bariatric surgery . PCOS . Polycystic ovaries
* Sandeep Aggarwal [email protected] Devender Singh [email protected] Kirit Arumalla [email protected] Vitish Singla [email protected] Ashraf Ganie [email protected] Neena Malhotra [email protected] 1
Department of Surgical Disciplines, All India Institute of Medical Sciences, Room no. 5034, New Delhi, India
2
Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India
3
Department of Gynaecology, All India Institute of Medical Sciences, New Delhi, India
Introduction Polycystic ovary syndrome (PCOS) is a common endocrinopathy of adolescents and reproductive age group females with a prevalence ranging from 5 to 18% [1]. It is characterized by oligomenorrhea, clinical signs of hyperandrogenism such as hirsutism, temporal balding, infertility, psychological symptoms such as anxiety, depression, metabolic syndrome features such as dyslipidemia, diabetes, increased cardiovascular disorders, and increased risk of ovarian and endometrial cancer [2]. PCOS refers to a female subtype of metabolic syndrome known as sy
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