Impact of osteoporosis and vertebral fractures on quality-of-life. a population-based study in Valencia, Spain (The FRAV
- PDF / 273,790 Bytes
- 10 Pages / 595.276 x 793.701 pts Page_size
- 68 Downloads / 188 Views
RESEARCH
Open Access
Impact of osteoporosis and vertebral fractures on quality-of-life. a population-based study in Valencia, Spain (The FRAVO Study) José Sanfélix-Genovés1,2*, Isabel Hurtado1, Gabriel Sanfélix-Gimeno1, Begoña Reig-Molla3 and Salvador Peiró1
Abstract Background: To describe the health related quality of life in a population sample of postmenopausal women over the age of 50 and resident in the city of Valencia (Spain), according to the presence/absence of osteoporosis and the severity of prevalent morphometric vertebral fractures. Methods: A cross-sectional age-stratified population-based sample of 804 postmenopausal women of 50 years of age and older were assessed with the SF-12 questionnaire. Information about demographic features, lifestyle, clinical features, educational level, anti-osteoporotic and other treatments, comorbidities and risk factors for osteoporosis were collected using an interviewer-administered questionnaire and densitometric evaluation of spine and hip and spine x-rays were carried out. Results: In the non-adjusted analysis, mild and moderate-severe vertebral fractures were associated with decreased scores in the SF-12 Physical Component Summary (PCS) but not in the Mental Component Summary (MCS), while densitometric osteoporosis with no accompanying fracture was not associated with a worse health related quality of life. In multivariate analysis worse PCS scores were associated to the age groups over 70 (-2.43 for 70-74 group and -2.97 for 75 and older), chronic conditions (-4.66, -6.79 and -11.8 according to the presence of 1, 2 or at least 3 conditions), obesity (-5.35), peripheral fracture antecedents (-3.28), hypoestrogenism antecedents (-2.61) and the presence of vertebral fracture (-2.05). Conclusions: After adjusting for confounding factors, the physical components of health related quality of life were significantly lower in women with prevalent osteoporotic vertebral fractures than in women -osteoporotic or not- without vertebral fractures.
Introduction Osteoporosis is a common condition characterized by decreased bone mass and increased susceptibility to fractures [1]. The most common clinical complications of osteoporosis are hip, wrist, and vertebral fractures. Vertebral fractures (VFX) are the most prevalent osteoporosis-related fractures but they are often asymptomatic, and their underdiagnosis and undertreatment is well documented [2,3]. Measures of Health Related Quality of Life (HRQoL) have gained increasing attention as relevant outcomes in clinical studies of osteoporosis [4,5]. These measures are * Correspondence: [email protected] 1 Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain Full list of author information is available at the end of the article
also used in epidemiological surveys, complementary to data on morbidity and health care utilization, to estimate the burden of disease and often to compare with other chronic diseases. Several instruments, both generic and disease targeted, have been used to examine HRQoL in os
Data Loading...
