Impact of short-term hydrocortisone intake on pituitary and adrenal function in healthy young male subjects
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ORIGINAL ARTICLE
Impact of short-term hydrocortisone intake on pituitary and adrenal function in healthy young male subjects Katia Collomp
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Virgile Amiot4 Barbara Robin3 Magnus Ericsson3 Corinne Buisson3 ●
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Received: 18 May 2020 / Accepted: 30 July 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose The aim of this study was to evaluate the impact of short-term therapeutic hydrocortisone intake on pituitary and adrenal function in healthy young male subjects. Methods Ten physically active men received 50 mg/per day of hydrocortisone at 8:00 a.m. for 5 days. Cortisol, DHEA, and ACTH concentrations in plasma, and cortisol and DHEA concentrations in saliva were determined the week before, just before (8:00 a.m.) and 2 h after (10:00 a.m.) drug ingestion on days 1, 3, and 5 of treatment and day 1 post treatment. Results Hydrocortisone intake induced a significant increase in both plasma cortisol (×3) and saliva cortisol (×10) concentrations 2 h after administration. Plasma and saliva DHEA concentrations were significantly decreased, as were plasma ACTH concentrations, 2 h after administration, with an increase in the cortisol/DHEA and cortisol/ACTH ratios. However, no change in cortisol, DHEA, ACTH, cortisol/DHEA, or cortisol/ACTH was observed 24 h after the last intake during treatment or post treatment, except for a downward trend in saliva DHEA at days 3 and 5. The correlations between plasma and saliva cortisol, DHEA, and cortisol/DHEA were significant: respectively, r = 0.80, r = 0.80, and r = 0.88. Conclusions Once-daily oral therapeutic administration of hydrocortisone for 5 days altered adrenal DHEA secretion by inhibiting pituitary ACTH, but this effect seemed transient without significant impairment of basal adrenal or pituitary function 24 h after administration. Given the high correlations between plasma and saliva, saliva samples may be offered as a sensitive surrogate for blood sampling to estimate adrenal and pituitary function. Keywords Cortisol DHEA ACTH Systemic administration Adrenal function alteration ●
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Introduction Short-term or chronic glucocorticoid (GC) administration is often prescribed to treat a large number of pathologies, most often by dermal, oral, intramuscular (IM) or intraarticular (IA) routes. Studies have clearly demonstrated that shortterm and chronic systemic GC administration, as well as peri/IA GC administration, considered as local, can significantly and durably alter hypothalamic–pituitary–adrenal (HPA) function. The suppression of HPA function seems to
* Katia Collomp [email protected] 1
CIAMS, Université d’Orléans, Orléans, France
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Université Paris-Saclay CIAMS, Orsay, France
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Département des Analyses, AFLD, Chatenay-Malabry, France
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Service de Médecine du Sport, CHR Orléans, Orléans, France
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be dependent on many factors, including the dose and the molecule administered and the administration route. The suppressant effect of long-acting betamethasone [1] on t
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