Impact of catheterization on shear-mediated arterial dilation in healthy young men
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ORIGINAL ARTICLE
Impact of catheterization on shear‑mediated arterial dilation in healthy young men Andrea Tryfonos1 · Matthew Cocks1 · Debar Rasoul2 · Joseph Mills2 · Daniel J. Green3 · Ellen A. Dawson1 Received: 27 April 2020 / Accepted: 10 August 2020 © The Author(s) 2020
Abstract Purpose Animal studies have shown that endothelial denudation abolishes vasodilation in response to increased shear stress. Interestingly, shear-mediated dilation has been reported to be reduced, but not abolished, in coronary artery disease (CAD) patients following catheterization. However, it is not known whether this resulted from a priori endothelial dysfunction in this diseased population. In this study, we evaluated shear-mediated dilation following catheterization in healthy young men. Methods Twenty-six (age: 24.4 ± 3.8 years, BMI: 24.3 ± 2.8 kg m−2, VO2peak: 50.5 ± 8.8 ml/kg/min) healthy males underwent unilateral transradial catheterization. Shear-mediated dilation of both radial arteries was measured using flow-mediated dilation (FMD) pre-, and 7 days post-catheterization. Results FMD was reduced in the catheterized arm [9.3 ± 4.1% to 4.3 ± 4.1% (P
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