Improvement of in vitro degradation of magnesium oxychloride cement for bone repair by chitosan
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Improvement of in vitro degradation of magnesium oxychloride cement for bone repair by chitosan Jing Wen1, Jianguo Liao1,* Yu Zhu1 1
, Qiwei Ying1, Hang Li1, Yanrui Mao1, Suyan Han1, and
Henan Key Laboratory of Materials on Deep-Earth Engineering, School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, China
Received: 19 June 2020
ABSTRACT
Accepted: 21 August 2020
Ideal inorganic bone cement used for bone repair should have high strength, and the speed of degradation should match the formation rate of new bone tissue. Magnesium oxychloride cement has excellent mechanical properties and non-toxicity to bone marrow stromal cells; however, its application has been hindered by its poor water resistance. In this study, the high-degradation material chitosan (CS) was added to magnesium oxychloride cement (MOC). The compressive strength, mass loss, ion release, and pH value of the composite MOC were analyzed and scanning electron microscopy, energy dispersive spectroscopy, X-ray diffraction, and Fourier transform infrared spectroscopy were conducted. The compressive strength was 45.4 ± 5.3 MPa in cements with 0.5-wt% CS and 2-wt% KH2PO4 soaked in SBF for 28 d, and the degradation rate reached 12.67 ± 0.5%. SEM observations showed good apatite formation of the surfaces of the MOC with 2-wt% KH2PO4 and with 0.5-wt% CS and 2-wt% KH2PO4. The results indicate that the modified MOC possesses good mechanical properties, degradation rate and biological properties. Therefore, it is a promising material for degradable bone filling.
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Springer Science+Business
Media, LLC, part of Springer Nature 2020
Introduction Affording unique and important functions, bone is the largest tissue in the human body. Due to illnesses, accidents or aging, millions of people suffer from bone defects [1]. Bone defect repair has always been a big challenge by surgeons and usually is carried out
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https://doi.org/10.1007/s10853-020-05292-0
by bone transplantation [2]. Currently, autogenous bone grafts and allograft bone transplantation are widely clinically used. Restorative treatment is also used, where the autogenous bone is removed. Consequently, the accepted sites result in pain, inflammation and other side effects. Moreover, allograft bone transplantation always results in immune rejection, viral infections, and slow healing rates.
J Mater Sci
Furthermore, the collection and restoration are costly and difficult [3]. Thus, the application of artificial bone replacement material is becoming a new treatment. Medical bone cements have many advantages, such as being simple to use and having arbitrary plasticity and self-curing. These can be used for shaping and repair, and thus, they have excellent potential application value [4, 5]. Magnesium oxychloride cement (MOC) is a cementation material made by mixing magnesium oxide (MgO) powder with a magnesium chloride (MgCl26H2O) solution [6], which has the advantages
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