In Situ and In Vivo Animal Models
An important property in any central nervous system drug is the ability to cross the blood–brain barrier (BBB) and to reach therapeutic concentrations in brain at safe and acceptable doses. Multiple parameters influence brain drug bioavailability, includi
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Margareta Hammarlund-Udenaes Elizabeth C.M. de Lange Robert G. Thorne Editors
Drug Delivery to the Brain Physiological Concepts, Methodologies and Approaches
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Margareta Hammarlund-Udenaes Elizabeth C.M. de Lange • Robert G. Thorne Editors
Drug Delivery to the Brain Physiological Concepts, Methodologies and Approaches
Editors Margareta Hammarlund-Udenaes Department of Pharmaceutical Biosciences Translational PKPD Research Group Uppsala University, Uppsala, Sweden
Elizabeth C.M. de Lange Target Site equilibration Group LACDR/Pharmacology, Leiden University Leiden, The Netherlands
Robert G. Thorne Pharmaceutical Sciences Division University of Wisconsin-Madison School of Pharmacy Madison, WI, USA
ISSN 2210-7371 ISSN 2210-738X (electronic) ISBN 978-1-4614-9104-0 ISBN 978-1-4614-9105-7 (eBook) DOI 10.1007/978-1-4614-9105-7 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2013954405 © American Association of Pharmaceutical Scientists 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the a
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