DNA Damage Detection In Situ, Ex Vivo, and In Vivo Methods and Proto
Recent advances in organic chemistry, fluorescent microscopy, and materials science have created an entirely new range of techniques and probes for imaging DNA damage in molecular and cellular biology. In DNA Damage Detection In Situ, Ex Vivo, and In Vivo
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Molecular Biology™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
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DNA Damage Detection In Situ, Ex Vivo, and In Vivo Methods and Protocols Edited by
Vladimir V. Didenko Department of Neurosurgery and Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
Editor Vladimir V. Didenko, MD, Ph.D. Department of Neurosurgery and Department of Molecular & Cellular Biology Baylor College of Medicine Houston, Texas USA [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-60327-408-1 e-ISBN 978-1-60327-409-8 DOI 10.1007/978-1-60327-409-8 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010938360 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Dedication To my loving mother
Preface The development of cellular sciences has now entered the stage which requires the evaluation of DNA damage at both the single-cell and the whole organism levels. New approaches are developed to satisfy this need, and the older established techniques were adapted to the task. Advances in organic chemistry, fluorescent microscopy, and materials science have created a whole new range of techniques and probe for imaging DNA damage in molecular and cell biology. The volume presents all major assays used in molecular and cell biology for the labeling of DNA damage in situ, ex vivo, and in vivo. It brings together recently introduced techniques, as well as those established earlier, which detect and quantify DNA damage at the scales ranging from subcellular to the level of a whole, living organism. Historically, many techniques which detect DNA damage were originally introduced to solve a utilitarian task of labeling apoptotic
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