In-vitro bioactivity of silicate-phosphate glasses using agriculture biomass silica
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B I O M A T E R I A L S S Y N T H E S I S A N D CH A R A C T E R I Z A T I O N Original Research
In-vitro bioactivity of silicate-phosphate glasses using agriculture biomass silica Damandeep Kaur1 M. S. Reddy2 O. P. Pandey1 ●
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Received: 12 September 2019 / Accepted: 12 July 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract In the present work, silica extracted from the agricultural waste material; rice husk (RH) was utilized for the synthesis of biocompatible glass of general composition SiO2-P2O5-CaO-MgO-MoO3. In the synthesized glasses P2O5 (5%) and CaO (25%) was kept constant whereas MgO and MoO3 was varied from 10% to 20% and 0% to 5% respectively. The structural, morphological, elemental and functional properties of silica as well as the derived glasses were analyzed by X-Ray Diffraction (XRD), Field Emission Scanning Electron Microscopy (FE-SEM), Energy Dispersive X-ray spectroscopy (EDX) and Fourier Transform Infrared (FTIR) spectroscopy techniques. The effect of MoO3 on the structural and thermal properties of silicate phosphate glasses has been studied in details. The bioactivity of as-synthesized glass samples were further evaluated after immersion in Simulated Body Fluid (SBF) solution which shows bioactive properties thus enabling them to be used as scaffolds in implant materials. Graphical Abstract
1 Introduction
* O. P. Pandey [email protected] 1
School of Physics and Materials Science, Thapar Institute of Engineering and Technology, Patiala 147004, India
2
Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala 147004, India
The basic goal of implant materials in human body is to make them compatible with body fluids. It requires physical as well as chemical compatibility with reduced effect of toxicity [1]. In this context bioactive glasses (BG) can play an important role as implant material as compared to synthetic implant materials due to their bone formation ability and non-toxic by-product resulting from the interaction with simulated body fluid (SBF). The interaction of implant material with body fluid occurs by ionic leaching of glass
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Journal of Materials Science: Materials in Medicine (2020)31:65
constituents followed by its deposition through silanol group formation on the surface of glass [2, 3]. The grown apatite layer helps in formation of tissues (soft/hard) and finally in bone generation. The above criterion is tested through in-vitro assays to design new glass compositions to be used as implant materials. In this category many compositions of glasses have been developed and tested for its biocompatibility. These were also studied for different applications as implant materials, scaffold formation, fibers, coatings and drug delivery systems [4, 5]. First bioglass was invented by Hench containing SiO2 as network former [6]. Silicate based glasses are preferred over P2O5 containing bioactive glasses because of their better mechanical properties [7]. On the other hand
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