In vivo performance analysis of silanized and coated nitinol wires in biological environment
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Invivoperformance analysisof silanized andcoated nitinol wires in biological environment Sarmita Sinha1, Jyotsana Priyadarshani2, Karuppasamy Bavya Devi3,c), Anyam Vijay Kishore4, Piyali Das4, Abhijit Chanda1,a), Soumen Das2, Mangal Roy3, Samit Kumar Nandi4,b) 1
Department of Mechanical Engineering, Jadavpur University, Kolkata 700032, India School of Medical Science and Technology, Indian Institute of Technology-Kharagpur, Kharagpur 721302, India 3 Department of Metallurgical and Materials Engineering, Indian Institute of Technology-Kharagpur, Kharagpur 721302, India 4 Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata 700037, India a) Address all correspondence to these authors. e-mail: [email protected] b) e-mail: [email protected] c) Present address: Department of Chemistry, Nims Institute of Engineering & Technology, Nims University Rajasthan, Jaipur-Delhi Highway (NH11C), Nims Institute of Engineering & Technology, Jaipur-303121, Rajasthan, India. 2
Received: 13 February 2020; accepted: 8 April 2020
Some interesting properties such as superelasticity, shape memory effect, kink resistance, good biocompatibility, biomechanical properties, and corrosion resistance made nitinol a popular biomaterial as stent and orthopedic implants. But surface modification is needed to control nickel leaching from its surface, making safe for human body. The aim of this study was to modify the nitinol surface by the silanization technique and electrophoretically deposited hydroxyapatite coating, and to conduct a detailed in vitro and in vivo investigation. Detailed in vitro investigation involved MTT assay with the human osteoblastic cells (MG63 cell) over a period of 5 days and confocal image study. In case of in vivo study, histological study, fluorochrome labeling study, and Micro-Ct study were conducted. The overall in vitro and in vivo results indicate that silanized nitinol samples are showing slightly better level of performance, but both the surface-modified samples are suitable as the potential bio-implant for orthopedic purpose.
Introduction Nitinol is a nickel–titanium metallic alloy with equiatomic composition which has exceptional physical and mechanical properties, shape memory effect, super-elastic properties, low elastic modulus, high strength, good corrosion resistance, and excellent biocompatibility [1, 2, 3]. These properties together with the similar biomechanical properties of human bone tissue make nitinol a promising biomaterial for orthopedic implant applications [4, 5]. But there are certain limitations as well. The corrosion property as well asdischarge of nickel ions of NiTi shape memory alloys (SMA) has restricted its use in human organisms [6]. Chemical and thermal treatments may cause to abolish or diminish the surface Ni content of the alloy vis-à-vis accelerate to form a biocompatible titanium oxide on the surface of the alloy [7]. But this oxide layer is reported to show poor bioactivity. Moreover, it does not promot
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