In vivo SPECT imaging of an 131 I-labeled PM 2.5 mimic substitute
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In vivo SPECT imaging of an 131I-labeled PM 2.5 mimic substitute Dong-Hui Pan1,2 • Jie Sheng2 • Xin-Yu Wang2 • Qian-Huan Huang2 Jun-Jie Yan2 • Li-Zhen Wang2 • Run-Ling Yang2 • Dong-Jian Shi1 • Yu-Ping Xu2 • Ming-Qing Chen1
•
Received: 24 May 2020 / Revised: 23 September 2020 / Accepted: 24 September 2020 / Published online: 10 November 2020 Ó China Science Publishing & Media Ltd. (Science Press), Shanghai Institute of Applied Physics, the Chinese Academy of Sciences, Chinese Nuclear Society and Springer Nature Singapore Pte Ltd. 2020
Abstract The health effects of ambient PM 2.5 and its potential mechanisms have generated considerable interest. In vitro cell studies and ex vivo animal experiments may not accurately determine the characteristics of PM 2.5 particles. To better understand their detailed mechanisms, we performed an in vivo study using single photon emission tomography (SPECT) imaging. To mimic the PM 2.5 particles, SiO2 nanoparticles modified by ethylene carbonate or polyvinyl pyrrolidone were labeled with 131I. After administration via inhalation, in vivo SPECT imaging of the radiolabeled particles in sprague dawley rats was performed. It was found that radioactivity accumulated in the lungs and trachea 6 and 24 h after administration. In addition, significant radioactivity was observed in the abdomen, including the liver and kidneys. The results were also confirmed by ex vivo autoradiography. This study
This work was supported by the National Natural Science Foundation of China (Nos. 31671035, 51803082), National Significant New Drugs Creation Program (No. 2017ZX09304021), Jiangsu Province Foundation (Nos. BK20170204, BK20161137), and Jiangsu Provincial Medical Innovation Team (Nos. CXTDA2017024, LGY2017088, QNRC2016628). & Yu-Ping Xu [email protected] & Ming-Qing Chen [email protected] 1
Key Laboratory of Synthetic and Biological Colloids, School of Chemical and Material Engineering, Ministry of Education, Jiangnan University, Wuxi 214122, China
2
Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
revealed that in vivo SPECT imaging could be an effective method for investigating the properties of PM 2.5 particles. Keywords PM 2.5 mimic substitute EC/SiO2 nanoparticles SPECT images 131I labeling
1 Introduction Air pollution has aroused widespread public health concerns in China with the rapid growth of the economy and industry. According to the global health observatory data from the WHO, almost 7 million people are killed by air pollution every year [1, 2]. Among them, particulates with aerodynamic diameters of less than 2.5 lm (PM 2.5), which comprise an air-suspended mixture of solid and liquid particles, have become the most criticized pollutant, attracting considerable attention. These particulates can penetrate human lungs and cause many adverse health effects, such as asthma, pneumonia, stroke, chronic bronchitis, and arrhythmia [3–5]. In addition, exposure
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