Increased expression of FGF1-mediated signaling molecules in adipose tissue of obese mice
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ORIGINAL PAPER
Increased expression of FGF1-mediated signaling molecules in adipose tissue of obese mice Youngshim Choi & Suhyeon Jang & Myung-Sook Choi & Zae Young Ryoo & Taesun Park
Received: 17 April 2015 / Accepted: 29 January 2016 # University of Navarra 2016
Abstract Fibroblast growth factors (FGFs) are pleiotropic growth factors that control cell proliferation, migration, and differentiation. Herein, we evaluated whether visceral adiposity of mice is accompanied by the alteration of signaling molecules mediated by fibroblast growth factor receptor 1 (FGFR1) induced by using two different male C57BL/6J mice models of obesity namely high-fat diet (HFD)-induced obesity for 12 weeks or mice with genetic deletion of leptin (ob/ob). Both HFD-fed and ob/ob mice exhibited significantly higher messenger RNA (mRNA) levels of FGF1, cyclin D (cycD), transcription factor E2F1, peroxisome proliferator-activated receptor-gamma 2 (PPAR-γ2), CCAAT-enhancerbinding protein alpha (C/EBPα), and adipocyte protein 2 (aP2) genes in their epididymal adipose tissues compared to those of the normal diet (ND)-fed and lean
Electronic supplementary material The online version of this article (doi:10.1007/s13105-016-0468-6) contains supplementary material, which is available to authorized users. Y. Choi : S. Jang : T. Park (*) Department of Food and Nutrition, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea e-mail: [email protected] M.
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