Glucocorticoid Signaling From Molecules to Mice to Man

This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to

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Jen-Chywan Wang Charles Harris Editors

Glucocorticoid Signaling From Molecules to Mice to Man

Advances in Experimental Medicine and Biology Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy

More information about this series at http://www.springer.com/series/5584

Jen-Chywan Wang • Charles Harris Editors

Glucocorticoid Signaling From Molecules to Mice to Man

Editors Jen-Chywan Wang, PhD Department of Nutritional Science & Toxicology University of California Berkeley Berkeley, CA, USA

Charles Harris, MD, PhD Division of Endocrinology Metabolism & Lipid Research Department of Internal Medicine Washington University School of Medicine St. Louis, MO, USA

ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-1-4939-2894-1 ISBN 978-1-4939-2895-8 (eBook) DOI 10.1007/978-1-4939-2895-8 Library of Congress Control Number: 2015945236 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)

Acknowledgements

JCW would like to thank his parents and family for support. He would also like to thank his graduate and postdoctoral mentors, Daryl Granner and Keith Yamamoto, his former and current lab members, and many collaborators and friends for their immense help during his research career. CH would like to thank his parents, Stewart and Helen; his wife, Audrey; and his son, Benjamin for their support. He would like to thank countless mentors who helped form his perspective as a physician scientist. Specifically, he would like to thank basic science mentors, Diane Lipscombe, Eugene M Johnson Jr