Increased levels of circulating IL-10 in persons recovered from hepatitis C virus (HCV) infection compared with persons
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BMC Research Notes Open Access
RESEARCH NOTE
Increased levels of circulating IL‑10 in persons recovered from hepatitis C virus (HCV) infection compared with persons with active HCV infection Dorcas Ohui Owusu1* , Richard Phillips2, Michael Owusu3, Fred Stephen Sarfo4 and Margaret Frempong5
Abstract Objective: Approximately 70% of all hepatitis C (HCV) infections develop chronic disease. Active or exacerbated chronic hepatitis C infection subsequently progress to liver disease. The role of T-cells secretions in achieving viral clearance is still not well understood. Thus, the current study was set to determine the relationship between the T cell cytokine profiles, biochemical parameters and persistent HCV infection or spontaneous recovery. Results: Twenty-five percent (41/163) of the anti-HCV positive participants had recovered from HCV and had significantly higher concentration of IL-10 compared to those with active HCV infection (P
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