Influence of endurance training-induced weight loss on the levels of ghrelin and obestatin of obese women with polycysti
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ORIGINAL ARTICLE
Influence of endurance training‑induced weight loss on the levels of ghrelin and obestatin of obese women with polycystic ovary syndrome Farzad Zehsaz1 · Negin Farhangi1 · Mehri Gahremani1 Received: 26 October 2019 / Accepted: 10 April 2020 © Springer-Verlag Italia S.r.l., part of Springer Nature 2020
Abstract Background Polycystic ovary syndrome is an observed plurimetabolic syndrome associated with central obesity and insulin resistance. Aims The purpose of the present study was to investigate the effects of 12-week training program on weight loss, serum ghrelin, acylated ghrelin, des-acylated ghrelin, and obestatin levels in obese sedentary women with polycystic ovary syndrome (PCOS). Methods To this end, thirty sedentary obese women with PCOS (mean age 31.07 ± 2.49 years, height 162.23 ± 2.39 cm, weight: 87.23 ± 4.48 kg, BMI 33.12 ± 0.92) were recruited from a multidisciplinary PCOS specialty clinic in Tabriz city in 2017 and evaluated before and after a 12-week training program, including 45 min per session of aerobic training at an intensity of 60–75% of age-predicted maximum heart rate (300 kcal/day). Results After the exercise program, body weight, waist circumference, and percentage body fat mass were decreased. Also, fasting glucose, insulin, and serum acylated ghrelin levels were significantly decreased (P 60% of V O2max)[16] but not after low and moderate intense bouts of activity [17]. These studies report that the acute effects of exercise on food intake and hunger mainly depend on the intensity of activity. Although, the common opinion among health professionals is that low to moderate intensity (40–59% VO2max) training is the most beneficial exercise prescription for weight loss, and proper for the prevention and treatment of obesity [12], the most of acylated ghrelin (AG) studies have concentrated on high intensity (≥ 70% VO2max) training [18]. A recent study observed that exercise-induced weight loss may increase fasting ghrelin and hunger sensations, but at the same time, it may also control the orexigenic drive by enhancing satiety after a meal and developing the sensitivity of the appetite control system [19]. These findings may account, in part for the mixed observations according to the role of ghrelin changes in weight regain [19]. Ravussin et al. [20] were the first to show findings with respect to the effect of exercise training on circulating ghrelin. These authors found that a three-month cycling intervention (two bouts/day to expend 4184 kJ/day) with related weight loss (6%) resulted in a 26% growth in fasting plasma ghrelin level within a sample of healthy, young, men. Contrarily, chronic overfeeding (351,456 kJ) over three months, adequate to increase body mass by 13% resulted in a significant reduction (18%) in fasting ghrelin [21]. These results suggest that ghrelin is more responsive to variations in energy balance/body weight and this result has been corroborated by others [21]. There is contradictory and very less research about the effect of exe
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