Insights into the interactions between DNA and an infinite clamp-like copper (II) complex
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Insights into the interactions between DNA and an infinite clamp‑like copper (II) complex Xinda Yang1 · Shunxin Gu1 · Qin Jiang1 · Yanqing Wang2 · Daqi Wang3 · Pengfei Shi1 Received: 31 March 2020 / Accepted: 27 May 2020 © Springer Nature Switzerland AG 2020
Abstract A Cu(II) complex [Cu2(phen)2(NAB)2(HO)]n (phen = 1, 10-phenanthroline and NABH = p-N, N-(2-hydroxyethyl)amino benzoic acid) was synthesized, and its structure was confirmed by X-ray diffraction. The structure of the complex appeared to be clamp-like, in which Cu(II) atoms adopt distorted square pyramidal geometry. Each Cu(II) is coordinated by two nitrogen atoms in phen ligand and two carboxyl oxygen atoms from each of the two NABH ligands. The clamp-like coordination units are bridged by adjacent hydroxyethyl groups into infinite 1D chain, which are further linked by extensive O···H hydrogen bonds and π–π interactions to form 3D networks. The titled complex displayed weak double-stranded DNA interaction activity. Spectroscopic and theoretical simulation results indicated that the complex attached onto DNA surface through hydrogen bonding with base pairs. Keywords Cu(II)-phenanthroline · Clamp-like · DNA interaction · Hydrogen bonding
Introduction Due to the interactions between cisplatin and DNA molecule in the nucleus, DNA is considered to be one of the biological targets for the antitumor activities of platinum-based drugs [1]. Molecules that can interact with DNA are thus studied and evaluated as potential antitumor drugs. Some small molecules have attracted particular attention because they can cleave DNA molecules under physiological conditions, which were detailedly assessed as potential artificial nuclease and have been widely studied in the fields of molecular
* Qin Jiang [email protected] * Pengfei Shi [email protected] 1
School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Function Control Technology for Advanced Materials, Jiangsu Ocean University, Lianyungang 222005, Jiangsu Province, People’s Republic of China
2
School of Chemistry and Environmental Engineering, Yancheng Teachers University, Yancheng 224002, Jiangsu Province, People’s Republic of China
3
School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, Shandong Province, People’s Republic of China
biology, biotechnology and therapeutic agents [2, 3]. The Cu(II) complex of 1,10-phenanthroline can intercalate into the minor groove of double-stranded DNA and combine with DNA through non-covalent binding and, in the presence of molecular oxygen and a reducing agent, act as an effective metallo-nuclease [4, 5]. Researchers have developed numerous Cu(II) complexes based on phen derivatives and studied exhaustively their binding and cleavage activities to DNA molecules. These complexes can be used as probes for examining the sequence specificities of DNA binding and even for studying the local conformation of DNA [6–8]. The antitumor activities of many Cu(II)-phen complexes have also been extensively evaluated, some of
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