Retroviruses and Insights into Cancer
Retroviruses cause chronic infections and insertion mutations in their hosts, often leading to the appearance of tumors. Studies of retrovirus-induced tumors have led to our understanding of many crucial concepts in cell and cancer biology, including the
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Jaquelin Dudley Editor
Retroviruses and Insights into Cancer
Editor Dr. Jaquelin Dudley Professor Section of Molecular Genetics and Microbiology The University of Texas at Austin One University Station A5000, 2506 Speedway, NMS 2.104 Austin, TX 78712-0162 [email protected]
ISBN 978-0-387-09580-6 e-ISBN 978-0-387-09581-3 DOI 10.1007/978-0-387-09581-3 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010933118 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Cover illustration: JSRV electron micrographs were provided courtesy of Kunio Nagashima and Massimo Palmarini. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
The inspiration for this volume is two-fold. First, we have just passed the 100-year anniversary of the discovery of avian leukosis viruses. Interest in these viruses was sparked by their association with tumors and, despite extensive experimental studies, the chapters in this book confirm that our knowledge of these intriguing organisms is far from complete. Second, many years of attending the International Workshop on Retroviral Pathogenesis convinced me that a series of reviews about cancer-inducing retroviruses was long overdue. Attendance at these meetings also allowed me both personal and professional access to the many fine scientists that participated in the completion of this monograph. I apologize to the regular participants in this meeting who could not contribute chapters; nevertheless, their ideas, enthusiasm and experimental work have substantially altered and enriched this exciting field. Although the study of oncogenic retroviruses has a long and rich history, the relatively recent characterization of complex human retroviruses, particularly human immunodeficiency virus (HIV) and human T-cell leukemia virus (HTLV), has reinforced the timeliness of this volume. As discussed in this monograph, HIV is not considered to be an oncogenic v
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