Interleukin-1 Gene Polymorphisms in Chronic Gastritis Patients Infected with Helicobacter pylori as Risk Factors of Gast
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ORIGINAL ARTICLE
Interleukin-1 Gene Polymorphisms in Chronic Gastritis Patients Infected with Helicobacter pylori as Risk Factors of Gastric Cancer Development Andrzej Hnatyszyn • Karolina Wielgus • Marta Kaczmarek-Rys • Marzena Skrzypczak-Zielinska • Marlena Szalata • Joanna Mikolajczyk-Stecyna Jerzy Stanczyk • Ireneusz Dziuba • Adam Mikstacki • Ryszard Slomski
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Received: 30 October 2012 / Accepted: 5 August 2013 Ó The Author(s) 2013. This article is published with open access at Springerlink.com
Abstract Epidemiological investigations indicated association of the Helicobacter pylori infections with the occurrence of inflammatory conditions of the gastric mucosa and development of chronic gastritis and intestinal type of gastric cancer. IL1A and IL1B genes have been proposed as key factors in determining risk of gastritis and malignant transformation. The aim of this paper was to evaluate association of interleukin-1 gene polymorphisms with chronic gastritis, atrophy, intestinal metaplasia, dysplasia and intestinal type of gastric cancer in H. pyloriinfected patients. Patients subjected to analysis represent group of 144 consecutive cases that suffered from dyspepsia with coexisting infection of H. pylori and chronic gastritis, chronic atrophic gastritis, intestinal metaplasia, dysplasia or gastric cancer. Molecular studies involved analysis of –889C[T polymorphism of IL1A gene and ?3954C[T polymorphism of IL1B gene. Statistical analysis of association of polymorphism –889C[T of gene
IL1A with changes in gastric mucosa showed lack of significance, whereas ?3954C[T polymorphism of IL1B gene showed significant association. Frequency of allele T of ?3954C[T polymorphism of IL1B gene was higher in group of patients with chronic gastritis, atrophy, intestinal metaplasia, dysplasia or intestinal type of gastric cancer (32.1 %) as compared with population group (23 %), v2 = 4.61 and p = 0.03. This corresponds to odds ratio: 1.58, 95 % CI: 1.04–2.4. Our results indicate that ?3954C[T polymorphism of IL1B gene increase susceptibility to inflammatory response of gastric mucosa H. pylori-infected patients and plays a significant role in the development of chronic gastritis, atrophy, intestinal metaplasia, dysplasia and the initiation of carcinogenesis.
A. Hnatyszyn Department of Internal Medicine, District Hospital, Drawsko Pomorskie, Poland
M. Szalata R. Slomski Department of Biochemistry and Biotechnology, Poznan University of Life Sciences, Poznan, Poland
A. Hnatyszyn Independent Public Hospital, Health Care Centre, Nowa Sol, Poland
J. Stanczyk Department of Pathology, Regional Hospital, Gorzow Wlkp, Poland
K. Wielgus Department of Biotechnology, Institute of Natural Fibres and Medicinal Plants, Poznan, Poland
I. Dziuba Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
M. Kaczmarek-Rys M. Skrzypczak-Zielinska M. Szalata J. Mikolajczyk-Stecyna R. Slomski (&) Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479 Poznan, Poland e-mail: slom
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