Helicobacter pylori
This book provides a detailed review of the most recent pathogenetic, diagnostic and therapeutic approaches in connection with Helicobacter pylori, along with priority areas in research and trends in clinical practice to address this significant pathogen
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Helicobacter pylori
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Hidekazu Suzuki • Robin Warren • Barry Marshall Editors
Helicobacter pylori
Editors Hidekazu Suzuki Medical Education Center Keio University School of Medicine Tokyo, Japan
Robin Warren The University of Western Australia and the Royal Perth Hospital Western Australia, Australia
Barry Marshall The University of Western Australia Western Australia, Australia
ISBN 978-4-431-55704-3 ISBN 978-4-431-55705-0 DOI 10.1007/978-4-431-55705-0
(eBook)
Library of Congress Control Number: 2016930559 © Springer Japan 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Japan KK
Preface
Before the 1970s, well-fixed specimens of the gastric mucosa were rare. Then the flexible endoscope was introduced. This enabled gastroenterologists to take numerous well-fixed small biopsies from the stomach. Gastric histology and pathology were clearly demonstrated. Whitehead accurately described it in 1972, including a feature he termed “active” gastritis. This involved only the superficial gastric epithelium, with polymorph infiltration and epithelial cell distortion. In June 1979 I was examining a gastric biopsy showing chronic inflammation and the active change. A thin blue line on the surface showed numerous small curved bacilli. These were clearly visible with a Warthin-Starry silver stain. They appeared to grow on the surface of the foveolar epithelial cells. Over the next 2 years I collected numerous similar cases. The changes were often much milder or more focal than the original biopsy, but the main features were usually similar, with chronic gastritis and usually some of the active change. These features could show considerable variation, from near normal to severe. In 1981 I met Barry Marshal, and we completed a clinicopathological study of 100 outpatients referred for gastroscopy. There was little relation between t
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