Helicobacter pylori
This book presents the current state of knowledge regarding the ability of Helicobacter pylori to colonize the gastrointestinal tract, the global epidemiology of H. pylori infection, transmission routes, the pathophysiology of H. pylori-related gastroduod
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Helicobacter pylori
Nayoung Kim Editor
Helicobacter pylori
Editor Nayoung Kim Bundang Hospital Seoul National University Seongnam-si, Gyeonggi-do South Korea
ISBN 978-981-287-705-5 ISBN 978-981-287-706-2 DOI 10.1007/978-981-287-706-2
(eBook)
Library of Congress Control Number: 2016944147 © Springer Science+Business Media Singapore 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Science+Business Media Singapore Pte Ltd.
Preface
After the discovery of Helicobacter pylori (H. pylori) by Prof. Barry Marshall and Robin Warren in 1982, the paradigm of gastroduodenal diseases fundamentally changed. Long-term colonization of H. pylori over the gastric mucosa caused a big change of microenvironment in the aspect of acid secretion by way of chronic inflammation, intriguing the balance of gastric hormones. In addition, active interaction of H. pylori and mucosal immunology causes intragastric diseases and gives impact on the extraintestinal diseases such as asthma and allergic disorders. Actually it is well known that disrupted balance between the host and intestinal microbiota produces changes in the mucosal immune system from microscopic to overt inflammation, and this also results in gut sensory-motor function and immune activity. Before this information of microbiota was reported, H. pylori, a gram-negative spiral bacterium, was found to be the main causal factor of gastritis, peptic ulcer, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. Accordingly, H. pylori has been classified as a group 1 gastric cancer carcinogen by the International Agency of Research on Cancer in 1994. Thus, these diseases could be categorized into a kind of infectious disease, and consequently eradication of H. pylori could be the key to the prevention of these diseases. However, the antibiotic resistance became the most important barrier for this
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