Intestinal Polyposis Syndromes Diagnosis and Management
This book provides a comprehensive, state-of-the art review of intestinal polyposis syndromes. The book reviews the most up-to-date clinical, management, and genetic information regarding the continually evolving colorectal condition that manifests as a p
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Intestinal Polyposis Syndromes
Diagnosis and Management
123
Intestinal Polyposis Syndromes
Lisa A. Boardman Editor
Intestinal Polyposis Syndromes Diagnosis and Management
Editor Lisa A. Boardman Division of Gastroenterology Mayo Clinic Rochester, MN, USA
ISBN 978-3-319-28101-8 ISBN 978-3-319-28103-2 DOI 10.1007/978-3-319-28103-2
(eBook)
Library of Congress Control Number: 2016932399 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Preface
The majority of colorectal cancers arise from sporadic polyps which are likely secondary to a combination of underlying acquired genetic mutations potentiated by environmental exposures. However, approximately 5 % of people who develop colorectal cancer will have an underlying hereditary colon cancer syndrome that is associated with an increased polyp burden. Classification of a patient into a specific polyposis syndrome is based on both clinical features and when possible genetic test results, yet determining the precise diagnosis is no small task, given the complexity of the histological variations and clinical features that may overlap between these syndromes. Similarly, the risks for extracolonic polyps or cancers as well as the risk for the development of colorectal cancer necessitate an extensive knowledge of how best to diagnose and manage polyp and cancer screening and surveillance for these patients. This book outlines the known hereditary polyposis syndromes including familial adenomatous polyposis (FAP) syndrome, attenuated FAP, MUTYH-associated polyposis, juvenile polyposis syndrome, Peutz–Jeghers syndrome, hereditary mixed polyposis syndrome, inflammatory cap polyposis, PTEN hamartoma syndrome, serrated polyposis syndrome, polymerase proofreading-associated polyposis, and seve
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