Introducing electrospun polylactic acid incorporating etched halloysite nanotubes as a new nanofibrous web for controlle
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ORIGINAL RESEARCH
Introducing electrospun polylactic acid incorporating etched halloysite nanotubes as a new nanofibrous web for controlled release of Amoxicillin Sareh Sepahi1 · Mohammadreza Kalaee2 · Saeedeh Mazinani3 · Majid Abdouss4 · Seyede Mahtab Hosseini4 Received: 19 July 2020 / Accepted: 14 October 2020 © Islamic Azad University 2020
Abstract The use of electrospun membrane is of great importance to control the drug release rate and improve the remedial performance. In this work, etched halloysite nanotubes (eHNTs) loaded with Amoxicillin (AMX) were imbedded in poly(lactic acid) (PLA) solution and were electrospun to make nanocomposite fibrous web. The morphology, uniformity, and size of electrospun (PLA/eHNTs/AMX) nanocomposite fibers were evaluated by scanning electron microscopy (SEM). Fouriertransform infrared spectroscopy (FTIR), tensile test, and water contact angle measurement were employed, respectively, to investigate the chemical structure, mechanical properties, and surface wettability of samples. Results showed that the presence of eHNTs does not considerably change the morphology of nanofibrous mats but partly increases the fiber diameter from 382 nm for PLA, to 1143 nm for PLA/HNTs 5%; while the mechanical properties are modified owing to eHNTs’ high modulus. In current work, the modulus is equal to 12.57 MPa and has increased significantly compared to PLA nanofibers, 4.29 MPa. According to drug release test, eHNTs as adequate nanocarrier reduced initial burst release and induced sustained AMX release profiles over 168 h. The amount of AMX release after 148 h for PLA/eHNTs/AMX mat is decreased by 73% and 12.5% in comparison with PLA/AMX and PLA/HNTs/AMX mats, respectively.
* Saeedeh Mazinani [email protected] Sareh Sepahi [email protected] Mohammadreza Kalaee [email protected] Majid Abdouss [email protected] Seyede Mahtab Hosseini [email protected] 1
Polymer Engineering Group, Faculty of Engineering, Qom University of Technology, Qom, Iran
2
Polymer Engineering Group, South Tehran Branch, Islamic Azad University, Tehran, Iran
3
New Technologies Research Center (NTRC), Amirkabir University of Technology, Tehran, Iran
4
Chemistry Department, Amirkabir University of Technology, Tehran, Iran
13
Vol.:(0123456789)
Journal of Nanostructure in Chemistry
Graphic abstract
Keywords Electrospinning · Controlled drug release · Poly (lactic acid) · Halloysite nanotubes
Introduction Electrospinning is considered as one of the most straightforward methods of lowest price to provide continuous scaffolds with micro-to-nanoscale topography and porous structure [1, 2]. Electrospun scaffolds are extensively applicable in different biomedical fields such as drug delivery and wound dressing [3, 4]. Indeed, drug delivery systems based on nanofiberous web have attracted increasing interests of researchers in pharmaceutical field. The controlled drug delivery systems are utilized to better therapeutic efficiency and safety of drugs by delivering them at a determined rate co
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