Iron Metabolism, Anemias. Diagnosis and Therapy Novel concepts in th
- PDF / 17,805,206 Bytes
- 215 Pages / 396.85 x 612.283 pts Page_size
- 3 Downloads / 195 Views
Springer-Verlag Wien GmbH
Dr. Manfred Wick Institute of Clinical Chemistry, Klinikum Grosshadem, University of Munich, Germany
Prim. Univ.-Prof. Dr. Wulf Pinggera Medical Department, General Hospital, Amstetten, Austria
Dr. Paul Lehmann Roche Diagnostics Gmbh, Mannheim, Germany
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concemed, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machines or similar means, and storage in data banks. © 1991, 1994, 1996, and 2000 Springer-Verlag Wien
Originally published by Springer-Verlag Wien New York in 2000 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product Liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceuticalliterature. Typesetting: Froschauer, A-3442 Langenrohr Printing: Adolf Holzhausens Nachfolger, A-1070 Wien
With 54 Figures
ISBN 978-3-211-83357-5 ISBN 978-3-7091-3909-7 (eBook) DOI 10.1007/978-3-7091-3909-7
Foreword Anemias are a worldwide problem. Severe anemia affects mainly the elderly. The WHO defines anemia as a hemoglobin concentration of less than 12 g/dl in women and less than 13 g/dl in men (World Health Organization. Nutritional Anemias. Technical Reports Series 1992; 503). According to these criteria 10 to 20 percent of women and 6 to 30 percent of men above the age of 65 years are anemic. In this book we place a new emphasis on the diagnosis and treatment of anemias of chronic disease (ACD) and renal anemias. Nevertheless, iron deficiency remains globally the most important cause of anemia. There have been so many advances in the diagnosis and, in particular, the therapy of the anemias in recent years that it appeared necessary to extend the spectrum of therapies and diagnostic methods described. Apart from renal and inflammatory anemias, new insights regarding the role of transferrin receptor, the physiology of erythropoietin production and the genetic defect as well as the pathogenesis of hemochromatosis demanded a major update of the book. The authors are grateful to Cheryl Byers, Annett Fahle and Kerstin Geiger of Roche Diagnostics, Heribert Bauer of Graphik-Art and Michael Katzenberger of the Springer-Verlag for their committed cooperation and their expert support in the publication of this book.
M. Wick W. Pinggera
March 2000
P. Lehmann
Table of Contents Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . • . .. 1 Physiological Principles of Iron Metabolism and Erythropoiesis ........................................... 3 Absorption of Iron . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Data Loading...
