Iterative framework for image registration and partial volume correction in brain positron emission tomography
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Iterative framework for image registration and partial volume correction in brain positron emission tomography Keisuke Matsubara1 · Masanobu Ibaraki1 · Miho Shidahara2 · Toshibumi Kinoshita1 on behalf of for the Alzheimer’s Disease Neuroimaging Initiative Received: 8 March 2020 / Revised: 4 October 2020 / Accepted: 7 October 2020 © The Author(s) 2020
Abstract Imprecise registration between positron emission tomography (PET) and anatomical magnetic resonance (MR) images is a critical source of error in MR imaging-guided partial volume correction (MR-PVC). Here, we propose a novel framework for image registration and partial volume correction, which we term PVC-optimized registration (PoR), to address imprecise registration. The PoR framework iterates PVC and registration between uncorrected PET and smoothed PV-corrected images to obtain precise registration. We applied PoR to the [11C]PiB PET data of 92 participants obtained from the Alzheimer’s Disease Neuroimaging Initiative database and compared the registration results, PV-corrected standardized uptake value (SUV) and its ratio to the cerebellum (SUVR), and intra-region coefficient of variation (CoV) between PoR and conventional registration. Significant differences in registration of as much as 2.74 mm and 3.02° were observed between the two methods (effect size 0.8), which resulted in considerable SUVR differences throughout the brain, reaching a maximal difference of 62.3% in the sensory motor cortex. Intra-region CoV was significantly reduced using the PoR throughout the brain. These results suggest that PoR reduces error as a result of imprecise registration in PVC and is a useful method for accurately quantifying the amyloid burden in PET. Keywords Amyloid · Image registration · Partial volume correction · PET
1 Introduction Positron emission tomography (PET) has been used to quantify biological processes in the cerebral cortex, particularly the deposition of amyloid beta plaques [1–4] and neurofibrillary tangles [5–8], which occur in neurodegenerative The information of “Alzheimer’s Disease Neuroimaging Initiative” was placed in acknowledgements section. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12194-020-00591-2) contains supplementary material, which is available to authorized users. * Keisuke Matsubara matsubara@akita‑noken.jp 1
Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels, Akita Cerebrospinal and Cardiovascular Center, 6‑10 Senshu‑Kubota‑machi, Akita 010‑0874, Japan
Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan
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disorders, including Alzheimer’s disease (AD). The low spatial resolution of PET measurements, typically 5–8 mm at full-width half-maximum (FWHM), results in spill-out radioactivity concentration from the region of interest (ROI) and spill-in from marginal regions; this phenomenon is known as a “partial volume effect” [9]. Morphological changes to ROI
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