Key Signaling Pathways in the Cardiovascular System
The activity of the heart and vessels is permanently modulated in response to electrical, mechanical and chemical signals to maintain cardiovascular system homeostasis. Some effects are rapidly manifested (e.g. contraction after an electrical stimulus), w
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Specific Cell Signaling
Tissue-Specific Cell Signaling
Joana Vieira Silva Maria João Freitas Margarida Fardilha •
Editors
Tissue-Specific Cell Signaling
123
•
Editors Joana Vieira Silva Laboratory of Signal Transduction, Department of Medical Sciences Institute of Biomedicine—iBiMED, University of Aveiro Aveiro, Portugal
Maria João Freitas Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine KU Leuven Leuven, Belgium
i3S—Instituto de Investigação e Inovação em Saúde University of Porto Porto, Portugal Laboratory of Cell Biology, Unit for Multidisciplinary Research in Biomedicine (UMIB) Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto Porto, Portugal
Margarida Fardilha Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine—iBiMED University of Aveiro Aveiro, Portugal
ISBN 978-3-030-44435-8 ISBN 978-3-030-44436-5 https://doi.org/10.1007/978-3-030-44436-5
(eBook)
© Springer Nature Switzerland AG 2020 Chapters 3 and 15 are licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). For further details see license information in the chapters. This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Cells have evolved to sense external chemical and physical cues, transduce the signals intracellularly through molecular cascades, and generate an appropriate response. The outcome can be an altered gene-expression pattern or a change in cell shape or metabolism to optimize the use of nutrients or to avoid toxins. In multicellular organisms, signal transduction is also a key determinant of ce
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