LC-MS in Drug Bioanalysis
High performance liquid chromatography – mass spectrometry (LC-MS) combines the separation power of liquid chromatography with the high sensitivity and selectivity of mass spectrometry. Th
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Q. Alan Xu Editors
Timothy L. Madden
LC-MS in Drug Bioanalysis
Editors Q. Alan Xu Department of Experimental Therapeutics University of Texas MD Anderson Cancer Center Houston, TX, USA
Timothy L. Madden Department of Experimental Therapeutics University of Texas MD Anderson Cancer Center Houston, TX, USA
ISBN 978-1-4614-3827-4 ISBN 978-1-4614-3828-1 (eBook) DOI 10.1007/978-1-4614-3828-1 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2012940715 © Springer Science+Business Media, LLC 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
The analysis of drugs in complex biological matrices plays a very important role in drug development, the conduct of clinical trials, and in therapeutic drug monitoring. Numerous analytical techniques have been developed to perform bioanalysis, which include immunoassays, gas chromatography-flame ionization detection (GC-FID), gas chromatography-mass spectrometry (GC-MS), high performance liquid chromatography-ultraviolet (HPLC-UV), high performance liquid chromatography-mass spectrometry (HPLC-MS or LC-MS), and high performance liquid chromatographytandem mass spectrometry (HPLC-MS/MS or LC-MS/MS). A huge selection of analytical columns and mobile phases provides f
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