Advances in Chemical Bioanalysis

Expert authors provide critical, in-depth reviews of available methods for retrieving selective information out of complex biological systems. Sensors, probes and devices are present and future tools of medicinal diagnostics, environmental monitoring, foo

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Frank-Michael Matysik  Editor

Advances in Chemical Bioanalysis

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Advances in Chemical Bioanalysis Series Editors: Frank-Michael Matysik, Regensburg, Germany Joachim Wegener, Regensburg, Germany

For further volumes: http://www.springer.com/series/11663

Aims and Scope Bioanalytical Reviews is the successor of the former review journal with the same name, and it will complement Springer’s successful and reputed review book series program in the flourishing and exciting area of the Bioanalytical Sciences. Bioanalytical Reviews (BAR) publishes reviews covering all aspects of bioanalytical sciences. It therefore is a unique source of quick and authoritative information for anybody using bioanalytical methods in areas such as medicine, biology, biochemistry, genetics, pharmacology, biotechnology, and the like. Reviews of methods include all modern tools applied, including chromatography (in its various forms), capillary electrophoresis, biosensors, bioelectroanalysis, fluorescence, mass spectrometry, NMR, IR/Raman, and other optical spectroscopies as well as methods related to bioimaging. In particular the series volumes provide reviews on perspective new instrumental approaches as they apply to bioanalysis, and on the use of micro-/nano-materials such as micro- and nanoparticles. Articles on μ-total analytical systems (μ-TAS) and on labs-on-a-chip also fall into this category. In terms of applications, reviews on novel bioanalytical methods based on the use of enzymes, DNAzymes, antibodies, cell slices, to mention the more typical ones, are highly welcome. Articles on subjects related to the areas including genomics, proteomics, metabolomics, high-throughput screening, but also bioinformatics and statistics as they relate to bioanalytical methods are of course also welcome. Reviews cover both fundamental aspects and practical applications. Reviews published in BAR are (a) of wider scope and authoratively written (rather than a record of the research of single authors), (b) critical, but balanced and unbiased; (c) timely, with the latest references. BAR does not publish (a) reviews describing established methods of bioanalysis; (b) reviews that lack wider scope, (c) reviews of mainly theoretical nature.

Frank-Michael Matysik Editor

Advances in Chemical Bioanalysis With contributions by S.M. Borisov • F. Canfarotta • M. Cindric • F.S. Gru¨newald • L. Gorton • C. Ha¨gerha¨ll • I. Klimant • F.‐M. Matysik • S.A. Patil • S.A. Piletsky • I.M. Perez de Vargas-Sansalvador • M. Quaranta • T. Riuttama¨ki (ne´e Rantanen) • T. Soukka

Editor Frank-Michael Matysik Institute of Analytical Chemistry University of Regensburg Regensburg Germany

ISBN 978-3-319-00181-4 ISBN 978-3-319-00182-1 (eBook) DOI 10.1007/978-3-319-00182-1 Springer Cham Heidelberg New York Dordrecht London Library of Congress Control Number: 2014941448 © Springer International Publishing Switzerland 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the righ