Light-triggered modulation of cell antioxidant defense by polymer semiconducting nanoparticles in a model organism
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Research Letter
Light-triggered modulation of cell antioxidant defense by polymer semiconducting nanoparticles in a model organism Maria Moros*†, Istituto di Scienze Applicate e Sistemi Intelligenti “E. Caianiello”, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Italy Anna Lewinska*, Department of Cell Biochemistry, Faculty of Biotechnology, University of Rzeszow, Pigonia 1, 35-310 Rzeszow, Poland Giada Onorato, Istituto di Scienze Applicate e Sistemi Intelligenti “E. Caianiello”, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Italy Maria Rosa Antognazza, Center for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, Via Pascoli 70/3, 20133 Milano, Italy Francesca Di Maria, Istituto per la Sintesi Organica e la Fotoreattivita’, Consiglio Nazionale delle Ricerche, Via P. Gobetti 101, 40129 Bologna, Italy Martina Blasio, Istituto di Scienze Applicate e Sistemi Intelligenti “E. Caianiello”, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Italy Guglielmo Lanzani, Center for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, Via Pascoli 70/3, 20133 Milano, Italy; Department of Physics, Politecnico di Mila, P.zza L. da Vinci 32, 20133 Milano, Italy Angela Tino, Istituto di Scienze Applicate e Sistemi Intelligenti “E. Caianiello”, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Italy Maciej Wnuk, Department of Genetics, Faculty of Biotechnology, University of Rzeszow, Pigonia 1, 35-310 Rzeszow, Poland Claudia Tortiglione, Istituto di Scienze Applicate e Sistemi Intelligenti “E. Caianiello”, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Italy Address all correspondence to Claudia Tortiglione at [email protected] (Received 21 March 2018; accepted 29 May 2018)
Abstract Photovoltaic organic semiconductors are emerging in many therapeutic applications, including drug delivery and optical control of cell function. However, for their safe use the possible concomitant elicitation of undesired responses in target cells need to be carefully evaluated. Here we describe molecular responses activated by semiconducting polymer nanoparticles based on poly(3-hexyl)thiophene (P3HT) in the model Hydra vulgaris, previously shown to respond to P3HT-NP photostimulation and showed a decrease in the total antioxidant capacity and an increase in the DNA and protein oxidation levels, paving the way to a novel use of photovoltaic devices to control intracellular redox equilibrium.
Introduction The possibility to remotely manipulate cellular fate and behavior in single cells has opened new frontiers for the investigation of cell signaling and gene regulation in living tissues. In this sense, physical stimuli such as electric fields and light irradiation have attracted a great deal of attention. Light offers many advantages to stimulate cell signaling, allowing high spatiotemporal resolution in a non-invasive way.[1] Optogenetics refers to the control of cellular behavior
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