Lipoxygenases in Inflammation
Oxidation of polyunsaturated fatty acids by lipoxygenases leads to a variety of fatty acid metabolites which play important roles in physiology but also in pathophysiology. Data accumulated during the last decade point to the fact that lipoxygen
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Dieter Steinhilber Editor
Lipoxygenases in Inflammation
Progress in Inflammation Research
Series editors Michael J. Parnham Fraunhofer IME & Goethe University Frankfurt, Germany Achim Schmidtko Goethe University Frankfurt, Germany
More information about this series at http://www.springer.com/series/4983
Dieter Steinhilber Editor
Lipoxygenases in Inflammation
Editor Dieter Steinhilber Institute of Pharmaceutical Chemistry Goethe University Frankfurt Frankfurt am Main Germany Series Editors Michael J. Parnham Fraunhofer IME & Goethe University Frankfurt Germany
Achim Schmidtko Goethe University Frankfurt Germany
Progress in Inflammation Research ISBN 978-3-319-27764-6 ISBN 978-3-319-27766-0 DOI 10.1007/978-3-319-27766-0
(eBook)
Library of Congress Control Number: 2016931316 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
Lipoxygenases oxidize polyunsaturated fatty acids and can generate lipid mediators which have a broad spectrum of physiological and pathophysiological functions. Data gathered during the last decades suggest that lipoxygenase metabolites are involved in host defence reactions and the cardiovascular system and contribute to the development of inflammatory and allergic diseases, cardiovascular disease, and cancer but are also involved in the resolution of inflammation. This Progress in Inflammation Research volume summarizes the physiological and pathophysiological functions of lipoxygenases.
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Contents
Lipoxygenases: An Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Dieter Steinhilber
1
5-Lipoxygenase . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Oliver Werz and Olof Ra˚dmark
7
Leukotriene A4 Hydrolase and Leukotriene C4 Synthase
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