Toll-like Receptors in Inflammation
Toll-like receptors (TLRs) are critical mediators of the innate immune response in mammals. This family of receptors recognizes a variety of microbial products or motifs and initiates the host response to infection. Examples include TLR4 which recognizes
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Series Editor Prof. Michael J. Parnham PhD Senior Scientific Advisor PLIVA Research Institute Ltd. Prilaz baruna Filipovic´a 29 HR-10000 Zagreb Croatia Advisory Board G. Z. Feuerstein (Wyeth Research, Collegeville, PA, USA) M. Pairet (Boehringer Ingelheim Pharma KG, Biberach a. d. Riss, Germany) W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands)
Forthcoming titles: Chemokine Biology – Basic Research and Clinical Application, Volume 2: Pathophysiology of Chemokines, K. Neote, G. L. Letts, B. Moser (Editors), 2005 The Hereditary Basis of Rheumatic Diseases, R. Holmdahl (Editor), 2006 Endothelial Dysfunction and Inflammation, A. Graham (Editors), 2006 In vivo Models of Inflammation, 2nd edition, C. S. Stevenson, D. W. Morgan, L. A. Marshall (Editors), 2006 (Already published titles see last page.)
Toll-like Receptors in Inflammation
Luke A. J. O’Neill Elizabeth Brint Editors
Birkhäuser Verlag Basel · Boston · Berlin
Editors Luke A.J. O`Neill Elizabeth Brint Cytokine Research Group Department of Biochemistry Trinity College Dublin Dublin 2 Ireland
Library of Congress Cataloging-in-Publication Data Toll-like receptors in inflammation / Luke A.J. O’Neill, Elizabeth Brint, editors. p. ; cm. -- (Progress in inflammation research) Includes bibliographical references and index. ISBN-13: 978-3-7643-7285-9 (alk. paper) ((to be completed)) ISBN-10: 3-7643-7285-0 (alk. paper)
Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the internet at http://dnb.ddb.de
ISBN-10: 3-7643-7285-0 Birkhäuser Verlag, Basel – Boston – Berlin ISBN-13: 978-3-7643-7285-9 Birkhäuser Verlag, Basel – Boston – Berlin The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained. © 2005 Birkhäuser Verlag, P.O. Box 133, CH-4010 Basel, Switzerland Part of Springer Science+Business Media Printed on acid-free paper produced from chlorine-free pulp. TCF ∞ Cover design: Markus Etterich, Basel Cover illustration: Printed in Germany ISBN-10: 3-7643-7285-0 ISBN-13: 978-3-7643-7285-9 987654321
e-ISBN: 3-7643-7441-1
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Contents
List of contributors
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vii
Preface . . . . . . . . . . .
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