Liquid Biopsy in Cancer Patients The Hand Lens for Tumor Evolution
This text is designed to provide readers with a useful and comprehensive resource and state-of-the-art overview about the new, growing and fast-expanding field of “liquid biopsy” for the management of cancer patients. The liquid biopsy represents an impor
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Antonio Giordano Antonio Russo Christian Rolfo Editors
Liquid Biopsy in Cancer Patients The Hand Lens for Tumor Evolution
Current Clinical Pathology Antonio Giordano, MD, PhD Philadelphia, PA, USA Series Editor
More information about this series at http://www.springer.com/series/7632
Antonio Giordano • Antonio Russo Christian Rolfo Editors
Liquid Biopsy in Cancer Patients The Hand Lens for Tumor Evolution
Editors Antonio Giordano College of Science and Technology Temple University Sbarro Institute for Cancer Research Philadelphia, Pennsylvania, USA
Antonio Russo Surgical and Oncological Sciences University of Palermo School of Medicine Palermo, Italy
Christian Rolfo Oncology University Hospital Antwerp Edegem, Antwerpen, Belgium
ISSN 2197-781X ISSN 2197-7828 (electronic) Current Clinical Pathology ISBN 978-3-319-55659-8 ISBN 978-3-319-55661-1 (eBook) DOI 10.1007/978-3-319-55661-1 Library of Congress Control Number: 2017938205 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Contents
1 Liquid Biopsy in Cancer Patients: The Hand Lens to Investigate Tumor Evolution���������������������������������������������������� 1 A. Russo, A. Giordano, and C. Rolfo 2 P recision Oncology: Present Status and Perspectives���������������� 7 Pierosandro Tagliaferri, Mariamena Arbitrio, Antonella Ierardi, Domenico Ciliberto, Maria Teresa Di Martino, and Pierfrancesco Tassone 3 Cancer Clonal Evolution and Intra-tumor Heterogeneity���������������������������������������������������������������������������������� 27 Daniele Fanale, Juan Lucio Iovanna, Antonio Giordano, Chris
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