Biomarkers in Cancer Therapy Liquid Biopsy Comes of Age
This book sheds new light on research into liquid biopsy biomarkers for cancer screening. The chapters in the first half address exosomes, circulating cell-free DNA and autoantibodies, and main solid cancers, along with companion biomarkers – all of which
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Biomarkers in Cancer Therapy
Hideaki Shimada Editor
Biomarkers in Cancer Therapy Liquid Biopsy Comes of Age
Editor Hideaki Shimada Gastroenterology Center (Surgery) Toho University Omori Medical Center Tokyo Japan
ISBN 978-981-13-7294-0 ISBN 978-981-13-7295-7 (eBook) https://doi.org/10.1007/978-981-13-7295-7 © Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
Despite improvements in surgical techniques, chemotherapy and/or radiotherapy, many patients with advanced cancers still suffer rapid recurrence of the disease and a poor outcome. Serum cancer biomarkers are useful tools to evaluate the biological features of cancer cells to predict recurrence, treatment response and patients’ survival. Based on the technical development of molecular analyses, various cancer biomarkers, molecular biomarkers and liquid biopsy have been applied for practice. In this book, recent developments in the field of cancer biomarkers and liquid biopsy are concisely reviewed. Clinical significance of serum extracellular vesicles, cellfree DNA, autoantibodies, angiogenic factors and cancer stem cells has been reviewed on various types of malignant tumors. These serum biomarkers have been developed for improving the quality of early diagnosis, monitoring the tumors, predicting treatment response and predicting patients’ survival. Thus, several serum biomarkers have potentially become the new molecular targets in cancer treatment. Tokyo, Japan
Hideaki Shimada
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Contents
Part I Various Strategies to Detect Cancer 1 Liquid Biopsy Diagnostics Using Extracellular Vesicles������������������������ 3 Makoto Sumazaki and Koji
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