Liver Metastasis: Biology and Clinical Management
Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver m
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Cancer Metastasis – Biology and Treatment VOLUME 16 Series Editors Richard J. Ablin, Ph.D., University of Arizona, College of Medicine and The Arizona Cancer Center, AZ, U.S.A. Wen G. Jiang, M.D., Wales College of Medicine, Cardiff University, Cardiff, U.K. Advisory Editorial Board Harold F. Dvorak, M.D. Phil Gold, M.D., Ph.D. Danny Welch, Ph.D. Hiroshi Kobayashi, M.D., Ph.D. Robert E. Mansel, M.S., FRCS. Klaus Pantel, Ph.D. Recent Volumes in this Series Volume 8: Cell Motility in Cancer Invasion and Metastasis Editor: Alan Wells ISBN 978-1-4020-4008-3 Volume 9: Cell Adhesion and Cytoskeletal Molecules in Metastasis Editors: Anne E. Cress and Raymond B. Nagle ISBN 978-1-4020-5128-X Volume 10: Metastasis of Prostate Cancer Editors: Richard J. Ablin and Malcolm D. Mason ISBN 978-1-4020-5846-2 Volume 11: Metastasis of Breast Cancer Editors: Robert E. Mansel, Oystein Fodstad and Wen G. Jiang ISBN 978-1-4020-5866-7 Volume 12: Bone Metastases: A Translational and Clinical Approach Editors: Dimitrios Kardamakis, Vassilios Vassiliou and Edward Chow ISBN 978-1-4020-9818-5 Volume 13: Lymphangiogenesis in Cancer Metastasis Editors: Steven A. Stacker and Marc G. Achen ISBN 978-90-481-2246-2 Volume 14: Metastasis of Colorectal Cancer Editors: Nicole Beauchemin and Jacques Huot ISBN 978-90-481-8832-1 Volume 15: Signal Transduction in Cancer Metastasis Editors: Wen-Sheng Wu and Chi-Tan Hu ISBN 978-90-481-9521-3 Volume 16: Liver Metastasis: Biology and Clinical Management Editor: Pnina Brodt ISBN 978-94-007-0291-2
Liver Metastasis: Biology and Clinical Management Edited by
Pnina Brodt Division of Surgical Research, Royal Victoria Hospital, McGill University Health Centre, Montreal, QC, Canada
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Editor Pnina Brodt Division of Surgical Research Royal Victoria Hospital McGill University Health Centre H3A 1A1 Montreal, QC Canada [email protected]
ISSN 1568-2102 ISBN 978-94-007-0291-2 e-ISBN 978-94-007-0292-9 DOI 10.1007/978-94-007-0292-9 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2011921120 © Springer Science+Business Media B.V. 2011 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
This book is dedicated to all the scientists who devote their lives to the study of disease for the betterment of human health.
Acknowledgement
The editor acknowledges with gratitude the hard work and dedication of all the authors who contributed excellent chapters to this book. Their knowledge and insights were an inspiration.
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Contents
1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Pnina Brodt Part I
1
Biology
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