Mesenchymal Stromal Cells Biology and Clinical Applications
Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad t
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Series Editor Kursad Turksen, Ph.D. [email protected]
For further volumes: http://www.springer.com/series/7896
Peiman Hematti
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Armand Keating
Editors
Mesenchymal Stromal Cells Biology and Clinical Applications
Editors Peiman Hematti Division of Hematology/Oncology Department of Medicine University of Wisconsin-Madison School of Medicine and Public Health Madison, WI, USA
Armand Keating Cell Therapy Program Princess Margaret Hospital University of Toronto Toronto, ON, Canada
ISBN 978-1-4614-5710-7 ISBN 978-1-4614-5711-4 (eBook) DOI 10.1007/978-1-4614-5711-4 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2012953270 © Springer Science+Business Media New York 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is a brand of Springer Springer is part of Springer Science+Business Media (www.springer.com)
To my wife Shirin, and my daughters Neeloufar and Faranak, for their love and support. Peiman Hematti To all my students and collaborators who have labored in this challenging and exciting area of research. Armand Keating
Foreword
Every tissue has some degree of mesenchymal cell contribution whether it be rare as with perivascular cells in the brain or abundant as in bone. In mesenchymal tissues like bone, there is a great deal known about lineage relationships and function, bu
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