LncRNA DDX11-AS1: a novel oncogene in human cancer
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REVIEW ARTICLE
LncRNA DDX11‑AS1: a novel oncogene in human cancer Yubin Feng1,2 · Maomao Wu3 · Shuang Hu1,2 · Xiaoqing Peng1,2 · Feihu Chen1,2 Received: 22 June 2020 / Accepted: 25 July 2020 © Japan Human Cell Society 2020
Abstract Long noncoding RNA (lncRNA) is a newly identified type of noncoding RNA with a length of more than 200 nucleotides. The latest research shows that lncRNAs play important roles in the occurrence and development of human tumours by acting both as carcinogenic genes and as tumour suppressor genes. LncRNAs plays a role in various biological processes, such as cell growth, apoptosis, migration and invasion. The newly discovered lncRNA DDX11-AS1 is abnormally highly expressed in various malignant tumours, such as hepatocellular carcinoma, colorectal cancer, osteosarcoma, bladder cancer, NSCLC and gastric cancer. DDX11-AS1 mainly regulates the expression of related genes through direct or indirect ways to perform its functions in carcinogenicity. These results indicate that DDX11-AS1 may be a marker or therapeutic target of tumours. This review summarizes the biological function and mechanism of DDX11-AS1 in the process of tumour development. Keywords lncRNA DDX11-ASA · Diagnosis · Therapeutic target · Prognosis Abbreviations LncRNA Long noncoding RNA DDX11-AS1 DDX11 antisense RNA 1 EZH2 Enhancer of zeste 2 polycomb repressive complex 2 subunit DNMT1 DNA methyltransferase 1 LATS2 Large tumour suppressor, homologue 2 CLDN7 Claudin 7 LAMB3 Laminin subunit beta3 CDK6 Cyclin-dependent kinase 6 SPC18 Signalling point code 18 IRS1 Recombinant insulin receptor substrate 1 PI3K Phosphatidylinositol 3-kinase AKT/PKB Protein kinase B AFP Alpha-fetoprotein Yubin Feng and Maomao Wu contributed equally to this work. * Xiaoqing Peng [email protected] * Feihu Chen [email protected] 1
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui Province, China
2
The Key Laboratory of Anti‐inflammatory and Immune medicines, Ministry of Education, Hefei, Anhui, China
3
Department of Pharmacy, Anhui Chest Hospital, Hefei, Anhui Province, China
HCC Hepatocellular carcinoma CRC Colorectal cancer GC Gastric cancer NSCLC Non-small cell lung cancer BC Bladder cancer EMT Epithelial-mesenchymal transition Bcl-2 B-cell lymphoma-2
Introduction Cancer, as a public health problem with high global mortality, has always been a focus of clinical research [1]. The latest research shows that in 2016, 1,685,210 patients were diagnosed with cancer in the United States, and 595,690 patients died, indicating a high mortality rate [2]. Research on the mechanism of cancer has been the focus of scientific research for a long time. An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play a key role in many cellular biological and pathological processes [3, 4]. According to the results of genome sequencing, only 2% of the human genome encodes protein; the remaining 98% do not have the a
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