Luminogen-functionalized mesoporous SBA-15 for fluorescent detection of antibiotic cefalexin
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Senlin Houb) The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, People’s Republic of China
Aibing Chenc) College of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China (Received 5 February 2018; accepted 27 March 2018)
A novel luminogen-functionalized SBA-15, denoted as SNT, was developed by incorporating tris (4-bromophenyl)amine (TBPA) into SBA-15 via a “fixation-induced emission” strategy. The emission of TBPA on the matrix of SBA-15 was greatly enhanced, making the SNT possible as a fluorescence sensor. Cefalexin, a typical antibiotic, was chosen as the model analyte to be assayed and sensitive detection performance was achieved. This is the first time for cefalexin to be detected by a fluorescent method. Moreover, the SNT can be recycled by simply washing with proper solvents then used for next detection. This work provides a strategy to greatly improve the emission characteristics of fluorophores, even if a mediocre small fluorophore. It can be extended to design practical fluorescent sensors with high performance and recyclability by this strategy.
I. INTRODUCTION
Antibiotics have been widely used for the treatment and prevention of bacterial infections. However, due to their easy access, the misuse and overuse of antibiotics have led to antimicrobial resistance and environment problems around the world. As biorefractory substances, antibiotics are regarded as new pollutants in aquatic environment and have been detected in surface waters in many areas including US, China, some European countries, etc. Massive antibiotics are released through effluents into soil and water, accumulated in drinking water and food, exerting negative influence on people’s health.1–4 Therefore, it is highly desirable to develop an effective way to detect antibiotics in aqueous solution. In the past decades, some analytical methods have been explored for qualitative/quantitative determination of antibiotics such as chromatographic methods, electrophoretic methods, microbiological assays, immunoassays, etc.5 Chromatographic methods are conventional and typical for antibiotic detection, while they are time-consuming and labor intensive.6 Electrophoretic methods are more Address all correspondence to these authors. a) e-mail: [email protected] b) e-mail: [email protected] c) e-mail: [email protected] DOI: 10.1557/jmr.2018.96
accurate but need complex sample pretreatment.7 Immunoassays are costly with antibodies or enzymes required.8 Fluorescent sensing is a powerful tool for the detection of chemical residues.9 But the aggregation-caused quenching effect is a great hurdle for practical applications of many fluorophores in poor solvents or solid states. By contrast, well-designed fluorophores with aggregation-induced emission (AIE) effect show exceptional strong emission upon molecular aggregation due to the restriction of intramolecular motion (RIM) process and are of great significance to technological applications. So far, AIE fluorophores hav
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