Lung Stem Cells in the Epithelium and Vasculature
This book covers the identification and role of endogenous lung stem cells in health and disease, particularly the most recent advances. In addition, it discusses the rapidly growing field of stem cells and cell therapy as it relates to lung biology and d
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Amy Firth Jason X.-J. Yuan Editors
Lung Stem Cells in the Epithelium and Vasculature
Stem Cell Biology and Regenerative Medicine
Series Editor Kursad Turksen, Ph.D. [email protected]
More information about this series at http://www.springer.com/series/7896
Amy Firth • Jason X.-J. Yuan Editors
Lung Stem Cells in the Epithelium and Vasculature
Editors Amy Firth Laboratory of Genetics Salk Institute for Biological Studies La Jolla, CA, USA
Jason X.-J. Yuan Department of Medicine The Univsersity of Arizona Tucson, AZ, USA
ISSN 2196-8985 ISSN 2196-8993 (electronic) Stem Cell Biology and Regenerative Medicine ISBN 978-3-319-16231-7 ISBN 978-3-319-16232-4 (eBook) DOI 10.1007/978-3-319-16232-4 Library of Congress Control Number: 2015938587 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Preface
Unfortunately lung disease remains a devastating cause of morbidity and mortality around the world. With an ever-increasing prevalence, the situation is not improving; indeed by 2020 COPD is expected to become the third leading cause of death worldwide. Most of the current therapeutic approaches for lung disease serve only to manage the symptoms. Lung transplantation remains one of few curative options and itself is associated with a host of other complications, particularly those due to lifelong immunosuppression. Like for many other diseases, there is a significant appeal for using stem cells in the treatment of lung disease. Before such approaches will come to fruition, it is necessary to establish in-depth knowledge of the role of stem cells in the human lung. The identity and function of stem cells in the developing and, in particular, the adult lung has been increasingly studied over the past
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