Medicinal plants in the adjunctive treatment of patients with type-1 diabetes: a systematic review of randomized clinica
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REVIEW ARTICLE
Medicinal plants in the adjunctive treatment of patients with type-1 diabetes: a systematic review of randomized clinical trials Farzaneh Barzkar 1 & Hamid Reza Baradaran 1 & Mohammad Ebrahim Khamseh 1 & Roya Vesal Azad 2 & Jalil Koohpayehzadeh 3 & Yousef Moradi 4 Received: 27 March 2020 / Accepted: 8 September 2020 # Springer Nature Switzerland AG 2020
Abstract Propose This study aims to systematically review the randomized controlled trials that address the effectiveness and safety of herbal medicine in patients with type 1 diabetes. Methods The Cochrane Library (latest issue); MEDLINE (until recent); EMBASE (until recent); AMED (Allied and Complementary Medicine Database) (until recent); and CINHAL (until recent) were searched electronically for the identification of trials until October 2019. Articles were initially screened based on title and abstract and then by full text by two independent authors. References of retrieved studies were hand-searched for further studies. Risk of bias was assessed according to the Cochrane handbook of systematic reviews of interventions. The results were summarized into GRADE (grading of recommendations, assessment, development and evaluation) tables. No meta-analysis was applicable as only one study was found for each intervention. Results Four RCTs were finally included in the systematic review with an overall moderate quality of conduct and low quality of reporting. The sample sizes were very small. The results of these RCTs show that cinnamon pills and Berberine/Silymarine compound capsules may decrease blood glucose indices from baseline, while fenugreek seeds and fig leaf decoction do not show any statistically significant effect. Conclusions The evidence is scarce and no recommendations can be made based on current evidence. Further trials with more rigorous methodology and stronger quality of reporting are needed to make conclusions. Keywords Medicinal plants . Herbal medicine . Type-1 diabetes . Systematic review
Introduction Diabetes mellitus is a chronic metabolic disorder that is marked by hyperglycemia resulting from defective insulin secretion, insulin action or both. Short-term complications
include diabetic ketoacidosis and the nonketotic hyperosmolar syndrome. These complications are commonly categorized as microvascular (retinopathy, nephropathy, neuropathy) and macrovascular (coronary artery disease, cerebrovascular disease, and peripheral vascular disease). Diabetes and its
* Hamid Reza Baradaran [email protected]
Yousef Moradi [email protected]
Farzaneh Barzkar [email protected]
1
Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
Mohammad Ebrahim Khamseh [email protected]
2
School of Public Health, Iran University of Medical Sciences, Tehran, Iran
Roya Vesal Azad [email protected]
3
Preventive Medicine and Public Health Research Center, Iran University of Medical Sciences, Tehran, Iran
Jalil Koohpayehzadeh [email protected]
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