Metronidazole
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Sensory axonal polyneuropathy: case report A 66-year-old woman developed sensory axonal polyneuropathy following treatment with metronidazole for prosthetic infection. The woman was hospitalised for paresthesias of the tongue and the limbs, weakness of the lower limbs and dysarthria evolving over 3 weeks. In her young age, she had met a car accident resulting in nerve palsy, for which she had undergone right hip replacement. Three months prior to the current admission, the hip prosthesis was replaced due to prosthetic infection. Since the surgery, she had had been receiving metronidazole [route and dosage not stated], continued until 2 days prior to the current admission. Upon arrival, neurological examination showed upbeat nystagmus, dysarthria, hypopalesthesia of the lower limbs, weakness of the left leg, lack of proprioception in hands and feet, ataxia of the left arm, and a subtle frontal syndrome. MRI showed bilateral red nucleus, olivary nucleus hyperintensity and bilateral subcortical white matter hyperintensity. Nerve conduction study demonstrated sensory axonal polyneuropathy. Owing to the absence of metronidazole treatment, the neurological symptoms markedly improved. The woman was discharged with only mild sensory symptoms persisting. Fernandez Garcia M, et al. An unsuspected toxic can solve a rare clinical case. European Journal of Neurology 27 (Suppl. 1): 746, May 2020. Available from: URL: https:// 803498378 onlinelibrary.wiley.com/doi/epdf/10.1111/ene.14308 [abstract]
0114-9954/20/1819-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
Reactions 29 Aug 2020 No. 1819
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