Metronidazole
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Metronidazole toxicity, neurotoxicity, encephalopathy and seizures: case report A 20-year-old man developed metronidazole toxicity, neurotoxicity, encephalopathy and seizures during treatment with metronidazole for amoebic liver abscess. The man was admitted due to altered mental status with seizures over the last three days. At admission, it was noted that he had been receiving metronidazole for amoebic liver abscess for the last 13 days (total cumulative dose 19.5g) [route and exact dosage not stated]. He denied consumption of any of the illicit drugs or alcohol. On physical examination, he was found to be drowsy and disoriented but without neck rigidity or cranial nerve deficits. The serum electrolytes, renal functions, blood glucose levels, complete blood counts, liver chemistry, coagulation profile and CSF examination were all found to be within normal range. A cerebral MRI revealed signal hyperintensity in both the cerebellar dentate nuclei, suggestive of drug toxicity. Eventually, he was diagnosed with metronidazole-induced neurotoxicity, encephalopathy and seizures. The man’s therapy with metronidazole was therefore discontinued, and was treated with unspecified with conservative treatment. He eventually regained the sensorium. Arora N, et al. Neurological complications during treatment of liver abscess: think of metronidazole toxicity. Tropical Doctor 50: 165-166, No. 2, 01 Apr 2020. Available 803500473 from: URL: http://doi.org/10.1177/0049475520903651
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Reactions 12 Sep 2020 No. 1821
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