Target Identification and Validation in Drug Discovery Methods and P
This second edition book explores breakthrough technologies in the field of drug target identification and validation. The volume emphasizes particularly revolutionary technologies, such as CRISPR-related screening, “big data,” and in silico approaches, a
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Jürgen Moll Sebastian Carotta Editors
Target Identification and Validation in Drug Discovery Methods and Protocols Second Edition
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Target Identification and Validation in Drug Discovery Methods and Protocols Second Edition
Edited by
Jürgen Moll Pharmacology and Translational Research, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria
Sebastian Carotta Department of Cancer Cell Signaling, Boehringer Ingelheim RCV GmBH & Co KG, Vienna, Austria
Editors Ju¨rgen Moll Pharmacology and Translational Research Boehringer Ingelheim RCV GmbH & Co KG Vienna, Austria
Sebastian Carotta Department of Cancer Cell Signaling Boehringer Ingelheim RCV GmBH & Co KG Vienna, Austria
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9144-0 ISBN 978-1-4939-9145-7 (eBook) https://doi.org/10.1007/978-1-4939-9145-7 Library of Congress Control Number: 2019932163 © Springer Science+Business Media, LLC, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Considering the incredible new developments in technologies over the last few years, this second edition of the book took care to cover breakthrough technologies in the field of drug target identification and validation. We are confident that the second edition will be as successful as the first, with the majority of chapters capturing recently emerging technologies. These new technologies include 3D cell culture and in particular
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