Microarray Technology and Cancer Gene Profiling

Cancer is a heterogeneous disease in most respects, including its cellularity, different genetic alterations and diverse clinical behaviors. Traditional molecular analyses are reductionist, assessing only one or a few genes at a time, thus working with a

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ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science DAVID KRITCHEVSKY, Wistar Institute ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research RODOLFO PAOLETTI, University ofMilan

Recent Volumes in this Series Volume 586 CURRENT TOPICS IN COMPLEMENT Edited by John D. Lambris Volume 587 NEW TRENDS IN CANCER FOR THE 21 S T CENTURY Edited by Antonio Llombart-Bosch, Jos6 Lopez-Guerrero and Vincenzo Felipo Volume 588 HYPOXIA AND EXERCISE Edited by Robert C. Roach, Peter D. Wagner and Peter H. Hackett Volume 589 NEURAL CREST INDUCTION AND DIFFERENTIATION Edited by Jean-Pierre Saint-Jeannet Volume 590 CROSSROADS BETWEEN INNATE AND ADAPTIVE IMMUNITY Edited by Peter D. Katsikis Volume 591 SOMATIC CELL NUCLEAR TRANSFER Edited by Peter Sutovsky Volume 592 REGULATORY MECHANISMS OF STRIATED MUSCLE CONTRACTION Edited by Setsuro Ebashi and Iwao Ohtsuki Volume 593 MICRO ARRAY TECHNOLOGY AND CANCER GENE PROFILING Edited by Simone Mocellin Volume 594 MOLECULAR ASPECTS OF THE STRESS RESPONSE Edited by Peter Csermely and Laszlo Vigh

A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.

Microarray Technology and Cancer Gene Profiling Edited by Simone Mocellin, M.D., Ph.D. Clinica Chirurgica II, Dipartimento di Scienze Oncologiche e Chirurgiche, University ofPadova, Padova, Italy

Springer Science+Business Media, LLC Landes Bioscience / Eurekah.com

Springer Science+Business Media, LLC Landes Bioscience / Eurekah.com

Copyright ©2007 Landes Bioscience and Springer Science+Business Media, LLC All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system; for exclusive use by the Purchaser of the work. Printed in the U.S.A. Springer Science+Business Media, LLC, 233 Spring Street, New York, New York 10013, U.S.A. http://www.springer.com Please address all inquiries to the Publishers: Landes Bioscience / Eurekah.com, 1002 West Avenue, Second Floor, Austin, Texas 78701, U.S.A. Phone: 512/ 637 6050; FAX: 512/ 637 6079 http://www.eurekah.com http://www.landesbioscience.com Microarray Technology and Cancer Gene Profiling, edited by Simone Mocellin, Landes Bioscience / Springer Science+Business Media, LLC dual imprint / Springer Science+Business Media, LLC series: Advances in Experimental Medicine and Biology

ISBN: 0-387-39977-1

While the authors, editors and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current