Microfluidic Devices for Novel Synthesis
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0965-S09-07
Microfluidic Devices for Novel Synthesis Kyung Choi Bell Labs, Murray Hill, NJ, 07974
Microfluidic Devices for Novel Synthesis We demonstrate here functional polymeric particle synthesis by employing a microfluidic approach. The functional polymer is MIP system (molecularly imprinted polymer), which can be produced by “molecular imprinting”, a general protocol for the preparation of “synthetic receptor or binding sites” with specific recognition for targeted organic molecules. The recognition of complex molecules and biological entities is a necessary component for fabricating chemical sensors, diagonostic bio-sensors, and for drug delivery systems. We have obtained homogeneous MIP’s microparticles, which may have high affinity receptor sites only by fabricating a microreactor.
INTRODUCTION In nanotechnology, fabricating more compact devices, which satisfy our growing demands in miniaturization are needed due to stringent requirements for high performance devices.1-9 Thus, incentive challenges in the development of new materials and device fabrications currently lead this technology. Since nanotechnology has been seeking precision on advanced electronics with enhanced device performances at low cost, new materials and devices are desperately required in this area. There are a lot of challenges for chemists and materials scientist to play an important role in this area by developing new materials and devices since nanotechnology is a part of the chemical domain, which builds up materials at the molecular level. For example, a number of nano-particles and functional polymers have been synthesized to bring strong impacts on this technology. We introduced here a microfluidic synthesis of novel functional polymers. In this study, molecularly imprinted polymer (MIP), has been employed to demonstrate a microfluidic synthesis for potential applications such as highly sensitive chemical or bio-sensors or devices. MIP system is a highly cross-linked macroporous theroset with both high internal surface areas and specific molecular recognition sites. MIP system can be provided by “molecular imprinting technique”, which is a general protocol for the preparation of synthetic receptor sites with molecular recognition function for organic molecules in cross-linked network polymers. In this case, synthesis of specific receptor sites is a key contributor to the affinity in molecular recognition.
Figure 1. Recognition sites in the MIP’s system. Functional monomers with molecular recognition sites react with template molecules (denoted as ‘T’) to produce prepolymerization complex as shown in Figure 1. Porogen is used to extract templates so that the polymerization complex can create specific receptor sites in the networks. Molecular recognition will take place by rebinding of the template molecule to those receptor sites. Since detection is elicited by change in the physicochemical properties of the interface, the development of high affinity binding sites on molecules is a key contributor to the achievement of high af
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