MicroRNAs in Cancer Translational Research
MicroRNA (miRNA) is a cutting-edge topic in the scientific and medical fields. This is a timely and specialized book focusing on the current understanding of miRNAs and the potential for their application in cancer diagnosis, prognosis, and therapeutic ta
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William C.S. Cho Editor
MicroRNAs in Cancer Translational Research
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Editor Dr. William C.S. Cho Queen Elizabeth Hospital Department of Clinical Oncology 30 Gascoigne Road Hong Kong SAR PR China [email protected]
ISBN 978-94-007-0297-4 e-ISBN 978-94-007-0298-1 DOI 10.1007/978-94-007-0298-1 Springer Dordrecht Heidelberg London New York © Springer Science+Business Media B.V. 2011 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
MicroRNAs (miRNAs) have a revolutionary impact on cancer research over recent years. These small non-coding RNAs emerge as important players in tumorigenesis, leading to a paradigm shift in oncology. The rapid discovery of many miRNA targets and their associated pathways has contributed to the development of miRNAbased therapeutics for cancer. These exciting findings reveal the potential of miRNA studies translating from bench to bedside applications. Thorough understanding of miRNAs in cancer translational research is apparently a prerequisite for all professionals involved and interested in this area. MiRNA is a cutting-edge topic in the scientific and medical fields, the identification of cancer-related miRNAs and their state-of-the-art treatment approaches proceed at a fast pace. These stimulating advances drove me to compile this unique book entitled MicroRNAs in Cancer Translational Research. Hong Kong, China January 2011
William C.S. Cho
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Contents
1 MicroRNAs in Cancer (An Overview) . . . . . . . . . . . . . . . . Manuela Ferracin, George A. Calin, and Massimo Negrini 2 The Role of MicroRNAs in Lung Cancer Development, Progression, and Metastasis . . . . . . . . . . . . . . . . . . . . . . Don L. Gibbons, Zain H. Rizvi, and Jonathan M. Kurie
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3 MicroRNAs in Breast Cancer . . . . . . . . . . . . . . . . . . . . . Suvi-Katri Leivonen
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4 MicroRNAs in Colorectal Cancer . . . . . . . . . . . . . . . . . . . Ondrej Slaby, Marek Svoboda, Jaroslav Michalek, and Rostislav Vyzula
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5 MicroRNAs in Gastric Cancer . . . . . . . . . . . . . . . . . . . . . Hidekazu Suzuki, Yoshimasa Saito, and Toshifumi Hibi
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6 MicroRNAs in Prostate Cancer: A Possible Role as Novel Biomarkers and Therapeutic Targets? . . . . . . . . . . . . . . . . Paolo Gandellini, Marco Folini, and Nadia Zaffaroni
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7 MicroRNAs in Hepatocellular Carcinoma . . . . . . . . . . . . . . Junfang Ji and Xin Wei Wang
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8 MicroRNAs in Cervical Carcinoma . . . . . . . . . . . . . . . . . . Jeong-Won Lee, Byoung-Gie Kim, and Duk-Soo Bae
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9 MicroRNAs in Esophageal Cancer . . . . . . . . . . . . . . . . . . Jian Gu and Xifeng Wu
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