Methods and Biostatistics in Oncology Understanding Clinical Researc
This book introduces and discusses the most important aspects of clinical research methods and biostatistics for oncologists, pursuing a tailor-made and practical approach.Evidence-based medicine (EBM) has been in vogue in the last few decades, particular
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Methods and Biostatistics in Oncology
Raphael L. C. Araújo • Rachel P. Riechelmann Editors
Methods and Biostatistics in Oncology Understanding Clinical Research as an Applied Tool
Editors Raphael L. C. Araújo Hospital do Câncer de Barretos Barretos, SP, Brazil
Rachel P. Riechelmann Department of Clinical Oncology AC Camargo Cancer Center São Paulo, SP, Brazil
ISBN 978-3-319-71323-6 ISBN 978-3-319-71324-3 (eBook) https://doi.org/10.1007/978-3-319-71324-3 Library of Congress Control Number: 2018936135 © Springer International Publishing AG, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer International Publishing AG part of Springer Nature The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Foreword
It is my pleasure to introduce this volume “Methods and Biostatistics in Oncology— Understanding Clinical Research as an Applied Tool.” It is a timely contribution to clinical research in oncology as we experience an unprecedented increase in the number of clinical scientists and clinical studies all around the world. Important advances in our understanding of several topics, such as genomics, immunology, targeted treatments, and biomarkers, capture headlines in the popular press. As translational efforts to use these advances in the clinic intensify, the need for appropriate clinical research methodology has never been greater. It is for this reason that this volume will serve an important need. Dr. Araújo’s and Dr. Riechelmann’s editing skills are apparent in the team of authors they have recruited and the topics they have chosen. Each of the book’s 20 chapters has been written by one or more internationally recognized experts in the field. The chapters cover substantial ground, starting from a his
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