Transgenic Mouse Methods and Protocols
The generation of genetically modified mice is absolutely crucial to gene function studies today, primarily because mice are genetically similar to man and because gene function studies in mice are in the context of a whole organism, making them particula
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Molecular Biology™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For other titles published in this series, go to www.springer.com/series/7651
Transgenic Mouse Methods and Protocols Second Edition Edited by
Marten H. Hofker University Medical Center Groningen, University of Groningen Departments of Pathology & Medical Biology Medical Biology Section, Molecular Genetics, Groningen, The Netherlands and
Jan M. van Deursen Departments of Pediatrics, Biochemistry and Molecular Biology Mayo College of Medicine, Rochester MN, USA
Editors Martin H. Hofker University Medical Center Groningen University of Groningen Departments of Pathology & Medical Biology Medical Biology Section, Molecular Genetics Groningen, The Netherlands [email protected]
Jan M. van Deursen, Ph.D. Departments of Pediatrics Biochemistry and Molecular Biology Mayo College of Medicine Rochester MN, USA. [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-60761-973-4 e-ISBN 978-1-60761-974-1 DOI 10.1007/978-1-60761-974-1 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010938364 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface Modern biomedical research is gradually tightening its grip on the genetic basis of common diseases by studying complete genomes, transcriptomes, and other complex biological components. Pivotal to this progress in building complex networks is the detailed knowledge of the individual components. Hence, functional studies of individual genes will remain crucial. To obtain this functional information, genetically modified mice are likely to stay at the center stage for the years to come. An important reason for this role is that mice are genetically very similar to man. Moreover, gene function studies in mice a
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