Mucin pattern reflects the origin of the adenocarcinoma in Barrett's esophagus: a retrospective clinical and laboratoria
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Mucin pattern reflects the origin of the adenocarcinoma in Barrett's esophagus: a retrospective clinical and laboratorial study Sergio Szachnowicz*1, Ivan Cecconello1, Ulysses Ribeiro1, Kiyoshi Iriya2, Roberto El Ibrahim2, Flávio Roberto Takeda1, Carlos Eduardo Pereira Corbett2 and Adriana Vaz Safatle-Ribeiro1 Address: 1Department of Gastroenterology, Digestive Surgery Division, University of São Paulo School of Medicine, São Paulo, Brazil and 2Department of Pathology, University of São Paulo School of Medicine, São Paulo, Brazil Email: Sergio Szachnowicz* - [email protected]; Ivan Cecconello - [email protected]; Ulysses Ribeiro - [email protected]; Kiyoshi Iriya - [email protected]; Roberto El Ibrahim - [email protected]; Flávio Roberto Takeda - [email protected]; Carlos Eduardo Pereira Corbett - [email protected]; Adriana Vaz SafatleRibeiro - [email protected] * Corresponding author
Published: 9 March 2009 World Journal of Surgical Oncology 2009, 7:27
doi:10.1186/1477-7819-7-27
Received: 13 November 2008 Accepted: 9 March 2009
This article is available from: http://www.wjso.com/content/7/1/27 © 2009 Szachnowicz et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Mucin immunoexpression in adenocarcinoma arising in Barrett's esophagus (BE) may indicate the carcinogenesis pathway. The aim of this study was to evaluate resected specimens of adenocarcinoma in BE for the pattern of mucins and to correlate to the histologic classification. Methods: Specimens were retrospectively collected from thirteen patients who underwent esophageal resection due to adenocarcinoma in BE. Sections were scored for the grade of intestinal metaplasia. The tissues were examined by immunohistochemistry for MUC2 and MUC5AC antibodies. Results: Eleven patients were men. The mean age was 61 years old (varied from 40 to 75 years old). The tumor size had a mean of 4.7 ± 2.3 cm, and the extension of BE had a mean of 7.7 ± 1.5 cm. Specialized epithelium with intestinal metaplasia was present in all adjacent mucosas. Immunohistochemistry for MUC2 showed immunoreactivity in goblet cells, while MUC5AC was extensively expressed in the columnar gastric cells, localizing to the surface epithelium and extending to a variable degree into the glandular structures in BE. Tumors were classified according to the mucins in gastric type in 7/13 (MUC5AC positive) and intestinal type in 4/13 (MUC2 positive). Two tumors did not express MUC2 or MUC5AC proteins. The pattern of mucin predominantly expressed in the adjacent epithelium was associated to the mucin expression profile in the tumors, p = 0.047. Conclusion: Barrett's esophagus adenocarcinoma shows either gastric or intestinal type pattern of mucin
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