MYB-NFIB Translocation by FISH in Adenoid Cystic Carcinoma of the Head and Neck in Nigerian Patients: A Preliminary Repo
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MYB-NFIB Translocation by FISH in Adenoid Cystic Carcinoma of the Head and Neck in Nigerian Patients: A Preliminary Report Adepitan A. Owosho1 · Olufunlola M. Adesina2 · Oluwole Odujoko3 · Olujide O. Soyele2 · Akinwumi Komolafe3 · Robert Bauer1 · Kallie Holte1 · Kurt F. Summersgill4 Received: 25 July 2020 / Revised: 18 August 2020 / Accepted: 20 August 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Adenoid cystic carcinoma (AdCC) is a relatively rare malignancy of head and neck sites such as the salivary glands, lacrimal gland, sinonasal region, and pharynx and may arise in other exocrine glands. The oncologic event in AdCC is the translocation between MYB proto-oncogene transcription factor (MYB) and nuclear factor I/B (NFIB) resulting in t(6;9)(q22-23;p23-24). We carried out a preliminary evaluation of MYB-NFIB translocation by fluorescence in-situ hybridization on seven archived formalin-fixed paraffin-embedded tissues of AdCC of Nigerian patients and its clinicopathologic features. Only 3 of the 7 cases were successfully hybridized, all featuring MYB-NFIB translocations with a range of 14.7–83.3% of translocated cells in 60 cells examined. The 3 translocation positive cases were located in the maxillary sinus, buccal mucosa and parotid. Their morphologic appearances were cribriform-solid (1) & cribriform (2) and classified as grades III (1) & I (2), respectively. These patients may potentially benefit from MYB-targeted anti-neoplastic therapy. Keywords MYB rearrangement · Adenoid cystic carcinoma · MYB-NFIB · Salivary gland tumors
Introduction Adenoid cystic carcinoma (AdCC) is the second most common salivary gland malignant neoplasm after mucoepidermoid carcinoma [1]. AdCC may arise in other exocrine glands of the tracheobronchial tree, lacrimal gland, breast, cervix, vulva, and prostate. AdCCs of the head and neck are characterized by protracted clinic course, extensive Adepitan A. Owosho and Olufunlola M. Adesina are Co-equal first authors. * Adepitan A. Owosho [email protected] 1
Missouri School of Dentistry, A.T. Still University, 800 W Jefferson Street, Kirksville, Missouri 63501, USA
2
Department of Oral and Maxillofacial Surgery and Oral Pathology, Faculty of Dentistry, Obafemi Awolowo University, Ile‑Ife, Nigeria
3
Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University Teaching Hospital, Ile‑Ife, Nigeria
4
Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
perineural invasion, metastasis, and local and distant recurrences [1–5]. Histologically, AdCC is a biphasic tumor of ductal and myoepithelial cells arranged in heterogeneous morphologic growth patterns: cribriform, tubular, and solid in that order of frequency. The solid type (containing > 30% of solid pattern) of AdCC is associated with increased risk of recurrence and poor prognosis [6]. The genetic hallmark and key oncologic event in AdCC is the balanced translocation between M
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